摘要
目的观察柔肝消癥饮对肝硬化大鼠肝组织结缔组织生长因子(CTGF)表达的影响,探讨其抗肝硬化的作用机制。方法采用复合因素造模法复制肝硬化大鼠模型,实验分组为正常组、模型组、阳性药(复方鳖甲软肝片)对照组和柔肝消癥饮高、低剂量组。观察柔肝消癥饮对肝硬化大鼠肝组织病理形态学以及肝组织CTGF表达的影响。结果模型组大鼠出现肝小叶损害,纤维组织增生,假小叶形成;肝组织CTGF表达明显增强。各治疗组肝脏病理损害较轻,肝组织CTGF表达明显减少。结论柔肝消癥饮通过显著抑制肝硬化大鼠肝组织CTGF的表达,以达到抗肝硬化的作用。
Objective To observe the effect of Rouganxiaozheng liquid on the expression of Connectivum Growth Factor（ CTGF） in liver tissue of hepatic cirrhotic rats. Methods The model of hepatic cirrhosis were made by composite factor,which were devided into five groups,that was normal group,model group,control group （ Fufangbiejiaruangan tablet） ,high and low Rouganxiaozheng group,the effect of Rouganxiaozheng on hepatic tissue Pathological histology and the expression of CTGF in liver tissue were observed. Results Compared with normal group,the normal hepatic lobules in model group were disappeared and fibroplasias formed nodus and false folial; The expression of CTGF in liver tissue were increased obviously. Compared with model group, the pathological histology of each treatment group were improved,the expression of CTGF in liver tissue were decreased apparently. Conclusion Rouganxiaozheng liquid could obviously decrease the expression of CTGF in liver tissue of cirrhosis rats,and resist hepatic cirrhosis.
出处
《中国现代药物应用》
2010年第15期1-2,共2页
Chinese Journal of Modern Drug Application
基金
河北省科技攻关计划课题(项目编号:03276196D-7)
关键词
柔肝消癥饮
肝硬化
结缔组织生长因子
Rouganxiaozheng liquid
Hepatic cirrhosis
Connectivum growth factor
