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Ⅱ、Ⅲ期乳腺癌术后三种放疗方式的比较研究 被引量:4

Comparison study of three irradiation methods for postoperative stage Ⅱ and III breast cancer
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摘要 目的:探讨Ⅱ、Ⅲ期乳腺癌术后适宜的胸壁和锁骨上区照射方式。方法:156例患者随机分成A、B、C三组,给予不同放疗方式。A组锁骨上区和胸壁给予常规电子线照射,2Gy/次,1次/d,5d/周,总量至50Gy。B、C组电子线放疗至32Gy后,分别改用4野调强和三维适形切线放疗,剂量均为DT18Gy分9次11d完成。比较三组不良反应和疗效。结果:三组放射性皮肤反应发生率、胸壁复发率无差异(P>0.05);放射性肺损伤发生率分别为32.7%、10.4%、22.6%(P<0.05),B组最低,A组最高;远处转移率分别为36.3%、8.3%、37.7%(P<0.01),B组最低,A、C两组无差异。结论:三种放疗方式在皮肤反应和局部控制率上无差别;电子线+4野调强能减少放射性肺损伤发生,而对控制远处转移发生的作用尚需进一步研究。 Objective: To evaluate the proper radiotherapy methods for postoperative stageⅡand III breast cancer in receiving radiotherapy on the chest wall and upper clavicle area. Methods: Total of 156 cases were divided into three groups according to different radiotherapy methods. Group A was given full rang electron-radiotherapy of 50Gy/25f.Group B and C were respectively given 18Gy/9f of four fields intensity modulated radiotherapy and three-dimensional conformal radiotherapy after conventional electron-radiotherapy of 32Gy/16f. The effect and side effect were compared. Results: There were no statistical differences in the incidence of radioactive dermatitis and rate of chest wall recurrence in three groups (P0.05). There were statistical differences in the occurrence of radiation- induced lung injury(P0.05) and rate of distant metastasis in three groups (P0.01). The occurrence of radiation-induced lung injury was lowest in group B and group A was the highest.For distant metastasis rate, the group B was the lowest and there were no differences between group A and group C. Conclusion: The three radiotherapy methods have same incidence of radioactive dermatitis and local recurrence rate . Conventional and four fields intensity modulated radiotherapy is able to significantly decrease the occurrence of radiation-induced lung injury. The role of controlling distant metastasis is unclear.
出处 《现代肿瘤医学》 CAS 2010年第8期1538-1540,共3页 Journal of Modern Oncology
关键词 乳腺癌 放射治疗 放疗方法 疗效 breast cancer radiation radiotherapy method effect
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