摘要
目的 :评价茶碱缓释片的体外释放与体内吸收的相关性 ,为其质量控制提供实验依据。方法 :用反相高效液相色谱法测定血浆中的茶碱浓度 ,按Wagner-Nelson公式计算一定时间内 2种茶碱缓释片的体内吸收百分率。在3种不同pH的介质中进行体外释放度试验 ,计算相应时间内的累积释放百分率。结果 :介质的pH变化对茶碱缓释片的体外释放度无明显影响。结论
OBJECTIVE:To evaluate the correlativity between in vitro release and in vivo absorption of theophylline sustained release tablets.METHOD:The theophylline concentration in human plasma was determined by a high performance liquid chromatography method.According to the Wagner-Nelson formula,the percentages of in vivo absorption of two theophylline sustained release tablets were calculated.In vitro release of theophylline in 3 mediums of different pH was tested and the accumulated release percentage was calculated.RESULTS:The variation of pH of mediums were no significant affect on in vitro release rate of theophylline.CONCLUSION:A good correlativity was showed between in vivo absorption and in vitro release of theophylline sustained release tablets.
出处
《中国现代应用药学》
CAS
CSCD
1999年第2期27-29,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
茶碱缓释片
高效液相色谱
生物利用度
theophylline,sustained release tablet,high performance liquid chromatography,in vitro/in vivo correlativity
