摘要
目的:探讨连续性肾脏替代治疗对慢性重度心力衰竭患者的临床价值。方法:选择慢性重度心力衰竭患者,测定血清C反应蛋白和N端利钠肽前体水平,比较其在常规治疗和连续性肾脏替代治疗前后的变化。结果:慢性重度心力衰竭患者血清C反应蛋白、血清N端利钠肽水平高于正常对照组(P<0.01);治疗后,连续性肾脏替代治疗组C反应蛋白、N端利钠肽前体较常规治疗组明显降低(P<0.01)。结论:连续性肾脏替代治疗可降低慢性重度心力衰竭患者血清C反应蛋白和N端利钠肽前体的水平,可在一定程度上干预慢性重度心力衰竭的发展及其预后。
Objective To evaluate the value of continuous renal replacement therapy to severe chronic heart failure.Methods Twenty patients with severe chronic heart failure were included in this study.Plasma concentrations of C-reactive protein and N-terminal pro-B-type natriuretic peptide were measured and compared the changes before and after conventional therapy or continuous renal replacement therapy.Results The plasma concentrations of C-reactive protein and N-terminal pro-B-type natriuretic peptide were higher in patients with severe chronic heart failure than those in control group（P0.01）.And after treatment,the concentrations decreased more significantly in continuous renal replacement therapy group than those in conventional therapy group（P0.01）.Conclusion Continuous renal replacement therapy can decrease the lever of C-reactive protein and N-terminal pro-B-type natriuretic peptide in patients with severe chronic heart failure,and may interfere the progression of severe chronic heart failure and improve the cardiac function and prognosis.
出处
《中华实用诊断与治疗杂志》
2010年第8期754-755,758,共3页
Journal of Chinese Practical Diagnosis and Therapy
关键词
心力衰竭
连续性肾脏替代治疗
C反应蛋白
N端利钠肽前体
Heart failure
continuous renal replacement therapy
C-reactive protein
N-terminal pro-B type natriuretic peptide
