摘要
目的:对比研究氯普鲁卡因与传统在产科硬膜外麻醉中应用的利多卡因的效应。方法:剖宫产患者100例,随机分为两组:实验组为3%盐酸氯普鲁卡因,对照组为2%利多卡因。均于硬膜外(L2～3)穿刺置管,试验量5ml,观察5min无全脊麻和导管误入血管后,间隔5min分次注入局麻药5ml(含肾上腺素1:20万),控制平面T8以下。观察麻醉起效时间、痛觉消失起始时间、运动阻滞起始时间、运动阻滞最大程度(Bromage评分)、痛觉恢复起始时间、运动恢复起始时间以及呼吸循环的变化和中枢神经系统反应。结果:实验组在麻醉起效时间、痛觉消失起始时间、运动阻滞起始时间与运动恢复起始时间皆短于对照组(P<0.05),在运动阻滞最大程度、痛觉恢复起始时间方面,两组无明显差异(P>0.05);两组在呼吸循环的改变无明显差异(P>0.05);两组均未见中枢神经系统的不良反应及过敏反应。结论:氯普鲁卡因应用于产科麻醉中起效快,作用时间与利多卡因相当。
Objective：To evaluate the anesthetic efficacy of chloroprocaine and lidocaine epidural anesthesia for caesarean section.Methods：We selected 100patients who took in the caesarean birth and stochastic were divided into the observation group（50cases）for 3% chloprocaine and the control group（50cases）for 2% lidocaine.5min after 5ml anesthetic test volume into epidural space（L2～3）,a bolus of 10ml anesthetic was given to each patient.Onset time of anesthesia,pain loss,motor block and the highest degree of motor block and the recovering time of pain,moving should be observed.The changes of respiration,circulation and the reaction of central nervous system also should be recorded.Results：The onset time of anesthesia,pain loss,motor block,moving recovering of the observation group was shorter than that in controls（P0.05）.There was no difference between both groups on the highest degree of motor block and the recovering time of pain（P0.05）.There was no difference in the changes of respiration,circulation between both groups（P0.05）.There was no obvious adverse effect in two groups on central nervous system.Conclusion：Chloroprocaine has a rapid onset in cesarean section,the action time of chloroprocaine is be equivalent to the lidocaine.
出处
《医学理论与实践》
2010年第8期918-919,922,共3页
The Journal of Medical Theory and Practice
关键词
氯普鲁卡因
利多卡因
剖宫产硬膜外阻滞
Chloroprocaine
Lidocaine
Epidural anesthesia for caesarean section
