1Mufson MA,Stanek RJ. Bacteremic pneumococeal pneumonia in one American city: a 20-year longitudinal study, 1978- 1997[J]. AmJ Med,1999,107:34S-43S.
2Waterer GW, Somes GW, Wunderink RG. Monotherapy may be suboptimal for severe pneumococcal pneumonia[J]. Arch Intern Med, 2001,161 : 1837-1842.
3Baddour LM,Yu VL,Klugman KP,et al. Combination antibiotic therapy lower smortality among severely ill patients with pneumoeoceal baeteremia[J]. Am J Respir Crit Care Med, 2004,170: 440-444.
4Rodriguez A, Mendia A, Sirvent JM,et al. for the CAPUCI Study Group. Combination antibiotic therapy improves survival in patients with community acquired pneumonia and shock [J]. Crit Care Med, 2007,35 : 1493-1498.
5Thomas P, Lodise TP, Kwa A, et al. Comparison of β-1aetam and maerolide combination therapy versus fluoroquinolone monotherapy in hospitalized veterans affairs patients with community-acquired pneumonia[J]. Antimicrob Agents Chemother, 2007,51 : 3977 3982.
6Metersky ML, Ma A, Houck PM, et al. Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones[J]. Chest, 2007,131 : 466-473.
7Jose GM. Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia:an observationaL, multicenter study comparing monotherapy with combination antibiotic therapy[J]. Crit Care Med, 2007,35 : 1888-1895.
8Aarts MA. Empiric antibiotic therapy for suspected ventila tor-associated pneumonia:a systematic review and meta analy sis of randomized trials[J]. Crit Care Med, 2008,36 (1) : 108 -117.
9Daren KH. Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator associated pneumonia[J]. Crit Care Med, 2008,36 (3) : 737-744.
10Fainstein V, Bodey GP, Etting L, et al. A randomized study of ceftazidime compared to ceftazidime and tobramycin for the treatment of infections in cancer patients[J]. J Antimicrob Chemother, 1983,12(Suppl A) :101-110.
8D.G.Musson,A.Majumdar,S.Holland,et al.Pharmacoki-netics of total and unbound ertapenem in healthy elderly sub-jects[J].Antimicrob Agents Chemother,2004,48(2):521-524.
9Rodríguez A,Mendia A,Sirvent JM,et al.Combination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock[J].Crit Care Med,2007,35(3):1493-1498.
10Garnacho-Montero J,Sa-Borges M,Sole-Violan J,et al.Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia:an observational,multicenter study comparing monotherapy with combination antibiotic therapy[J].Crit Care Med,2007,35(8):1888-1895.
