摘要
目的:通过检测孕中期孕妇血清学甲胎蛋白(APF)、游离β-绒毛膜促性腺激素(Freeβ-hCG)、非结合雌三醇(uE3),进行唐氏综合征(Down's syndrome,DS)、18三体综合征和神经管缺陷(neural tube defect,NTD)的无创性产前筛查。方法:采用时间分辨荧光免疫分析法,对1641例16～20+6周孕妇进行血清AFP、Freeβ-hCG、uE3检测,结合孕妇年龄、孕周及体重等因素,经专用软件进行分析校正,计算风险率,对唐氏综合征和18三体综合征高风险孕妇,进行羊水细胞染色体核型分析。结果:1641例孕妇中筛查出高危孕妇98例,其中唐氏高风险孕妇73例,18三体综合征高风险孕妇4例,神经管畸形高风险孕妇21例;95例选择羊水细胞染色体分析的产前诊断,确诊唐氏综合征1例,18三体综合征1例。结论:孕中期血清三联筛查是可靠、有效的产前筛查方案,结合产前诊断可以有效降低缺陷儿出生,提高出生人口素质。
Objective：To detect Down＇s syndrome （DS）, trisomy 18 and neural tube defect （NTD） in prenatal care by maternal serum markers.Methods：The AFP, Free β-hCG and uE3 in1641 pregnant women at about 16th～20＋6th weeks＇gestation was measured by the time-discerment fluorescence analysis, and the risk rate was calculated by professional computer software.Results：There are 98 high risk gravidas including 21 neural tube defects, 4 trisomy 18 and 73 Down＇s syndrome gravidas in 1641 gravidas.In 95 high risk gravidas who choice the karyotype analysis in amniotic fluid for further diagnosis, 1 Down＇s syndrome and 1 trisomy 18 were diagnosed.Conclusion：The triple test in second trimester is safe and effection prenatal screening protocol.Triple test and prenatal diagnosis play a very significant role in decreasing fetal bith defects and improving new born population quality.
出处
《现代生物医学进展》
CAS
2010年第14期2679-2681,共3页
Progress in Modern Biomedicine
关键词
妊娠中期
出生缺陷
产前筛查
产前诊断
Second trimester
Bith defect
Prenatal screening
Prenatal diagnosis
