摘要
目的 探讨环氧化酶-2（COX-2）及血管内皮细胞生长因子（VEGF）对妊娠滋养细胞肿瘤发生发展及预后估计的作用.方法 采用免疫组化SABC法检测COX-2、VEGF在正常绒毛和妊娠滋养细胞疾病中的表达.结果 妊娠滋养细胞肿瘤组较正常绒毛及葡萄胎组COX-2、VEGF的表达率均明显增高（P＜0.01）;妊娠滋养细胞肿瘤中,COX-2与VEGF的表达呈正相关（r=0.795,P＜0.01）.结论 COX-2与VEGF的高表达协同积累可促使滋养细胞恶性转化,提示预后不良.
Objective To explore the role of COX-2 and VEGF in oncongensis and development of gestation-al trophoblastic disease,and evaluate prognosis of gestational trophoblastic tumor. Methods The expression of COX-2 and VEGF in normal chorion of early gestation and in gestational trophoblastic disease were detected by immunohis-tochemistry. Results In gestational trophoblastic tumor group,the positive rate of COX-2 and VEGF were significantly highter than that of normal chorion of early gestation group and the hydatidiform mole group respectively （ P 〈 0.01）. There were positive correlation between COX-2 and VEGF in gestational trophoblastic tumor （ r = 0.795, P 〈 0.01）. Conclusion The collaborative and over expression of COX-2 and VEGF were probably associated with the malignant change of trophoblastic cell,which suggest the worse prognosis of the gestational trophoblastic disease.
出处
《中国基层医药》
CAS
2010年第15期2037-2039,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
基金项目：广东省汕头市重点科技计划项目（2009020）
关键词
妊娠滋养细胞疾病
环氧化酶-2
血管内皮生长因子
免疫组织化学
Gestational trophoblastic disease
Cycloxygenase-2
Vascular endothelial growth factor
Immuno-histochemistry
