摘要
Nogo受体(NgR)作为髓鞘相关抑制分子受体,在中枢神经损伤和再生抑制过程中起关键作用。近年来,包括其轴突生长抑制、细胞移动调节等众多功能的发现,使Nogo受体的研究受到了神经医学界和药学界更为广泛的重视。本文综述了NgR复合物的组成和在神经损伤和再生过程中的功能,重点探讨了NgR在某些疾病发生和发展的过程中的作用,以及以NgR为药物开发靶点的潜在应用,为将来以NgR为靶点的药物开发和相关疾病的临床治疗提供有益的参考。
Since the multi-functions on central neural injury and regeneration,including arresting neurite outgrowth and cell migration modulation,have been revealed in recent years,Nogo receptor （ NgR） acting as a point of convergence in signal transduction for several myelin-associated inhibitors is catching more and more attention. The composition and multiple functions of Nogo receptor complex are reviewed in this article,focusing on the new roles of this receptor complex in the occurrence and development of central nervous system （ CNS）-related diseases,as well as its potential to be new molecular handles for the design of therapeutic interventions. This may provide a meaningful basis for the development of an effective NgR targeting treatment for several CNS-related diseases in the future.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2010年第4期306-311,共6页
Journal of China Pharmaceutical University
基金
国家"重大新药创制"科技重大专项资助项目(No.2009ZX09302)
国家自然科学基金资助项目(No.30670793)
江苏省自然科学基金资助项目(No.BK2009296)~~
