摘要
目的探讨光学相干断层成像评价动脉粥样硬化的价值。方法清洁级雄性新西兰大耳白兔20只,电脑随机数字法随机分为模型组10只(内膜损伤加高脂饮食)和对照组10只。实验前,实验第6周及第12周空腹12h,采集兔股动脉血行血清总胆固醇(total cholesterol,TC),三酰甘油(triglyceride,TG),低密度脂蛋白(low density lipoprotein cholesterol,LDL),高密度脂蛋白(high density lipoprotein cholesterol,HDL),极低密度脂蛋白(very low density lipoprotein cholesterol,VLDL)浓度检测;实验第1周末对模型组兔进行腹主动脉球囊拉伤;实验第12周末对兔行腹主动脉造影及光学相干断层成像检查。结果第6周及第12周模型组兔血清TC,TG,LDL,HDL,VLDL浓度均较对照组增加,差异有统计学意义(P<0.05);光学相干断层成像在模型组发现内膜增生,巨噬细胞浸润,脂质斑块形成,而动脉造影未观察到两组存在差别。结论光学相干断层成像诊断动脉粥样硬化的价值高于动脉造影。
Objectives To evaluate the value of optical coherence tomography in diagnosis of atherosclerosis. Methods We divided 20 white clean-class New Zealand male rabbits into model group （balloon injury added high-fat diet） and control group. Each group included 10 rabbits. Before experiment and at 6^th and 12^th week of the experimental section, the rabbits kept limosis for 12 h. Then we collected the blood from their femoral artery for inspecting total cholesterol （TC）, triglyceride （TG） ,low-density lipoprotein （LDL）, high-density lipoprotein （HDL） very low-density lipoprotein （VLDL）. On the end of the first week, we made the abdominal aortic balloon injury in model group. On the end of the 12^th week, we made the arteriography and the conducted optical coherence tomography examination. Results Serum concentrations of TC, TG, LDL, HDL, VLDL at the 6^th and 12^th week were significantly higher in model group than those in control group （P〈0.05）. Model group could be expressed as intimal hyperplasia, macrophages cell proliferation, lipid plaque formation by optical coherence tomography examination, while arteriography found nothing in the two groups. Conclusions optical coherence tomography has a higher diagnostic value than the arteriograpby for arteriosclerosis.
出处
《岭南心血管病杂志》
2010年第4期321-324,共4页
South China Journal of Cardiovascular Diseases
基金
2009年安徽省卫生厅科研课题(项目编号:09B101)
