摘要
对青岛产仿刺参体内皂苷类成分进行分离及结构鉴定,确定其皂苷的主要组成及比例。应用大孔树脂,正相硅胶柱层析和半制备型HPLC对青岛产仿刺参体内的皂苷成分进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。共分离并鉴定3种三萜皂苷类化合物,分别为Cladoloside B(1),Holotoxin A1(2)和Holotoxin B1(3)。青岛海域仿刺参体内的皂苷组成主要为Cladoloside B(1),Holotoxin A1(2)和Holotoxin B1(3),比例约为1∶4.5∶1.7。
To study the constituents and proportion of triterpene glycosides from sea cucumber S.japonicus of Qingdao,Triterpene glycosides were separated and purified by macroporous resin,Si-gel chromatography and semi-preparative HPLC.Three triterpene glycosides were found and were identified as cladoloside B（1）,holotoxin A1（2） and holotoxin B1（3） with an approximate ratio of 1∶4.5∶1.7 based on the chemical evidence and spectral data.
出处
《中国海洋大学学报（自然科学版）》
CAS
CSCD
北大核心
2010年第8期60-65,共6页
Periodical of Ocean University of China
基金
国家科技支撑计划项目(2008BAD94B05)资助
关键词
仿刺参
海参
三萜皂苷
Apostichopus japonicus Selenka
sea cucumber
triterpene glycoside
