摘要
目的:探讨病毒性脑炎患儿血清神经元特异性烯醇化酶(NSE)水平的变化及意义。方法:应用酶联免疫吸附法(ELISA)对病毒性脑炎患儿急性期和恢复期血清神经元特异性烯醇化酶的水平测定,并与22例健康儿进行比较。结果:病毒性脑炎患儿急性期14.64±3.39μg/L血清神经元特异性烯醇化酶浓度明显升高,较对照组9.67±2.29μg/L有显著差异,具有统计学意义(P<0.05),恢复期11.40±2.13μg/L与急性期14.64±3.39μg/L比较明显下降,有显著性差异(P<0.05)。结论:病毒性脑炎患儿血清中神经元特异性烯醇化酶浓度明显升高,其水平与疾病的发生发展和病情严重程度有关,可作为判断病毒性脑炎患儿脑组织损伤的客观指标之一。
Objective ：to investigate the changes and clinical significance of serum neuron -specific enolase levels in pediatric patients with viral encephalitis. Methods： The concentration of neuron - specific enolase （NSE） in serum were measured by enzyme linked immunosorbent sorbent assay （ELISA） method when the patients were in acute stage and convalescent period. Twenty -two healthy children served as controls. Results： The serum neuron -specific enolase levels of the patients in acute stage （ 14. 64 ±3.39 ） μg/L were significantly higher than those of the control group （9. 67 ±2. 29 ） μg/L, and there were significant difference between viral encephalitis group and the control group（ P 〈 0. 05 ）. Their levels in convalescent stage （ 11.40±2. 13 ） μg,/L were significantly lower than those of the cases in acute stage（ 14. 64 ±3.39）μg/ L（ P 〈 0. 05 ）. Conclusion： The serum levels of neuronspecific enolase in the children with viral encephalitis raise significantly, their levels in children connected significantly with the advance and the condition of viral encephalitis. NSE in serum maybe used as an objective standard of degree of brain injury.
