摘要
目的探讨基质金属蛋白酶-2(MMP-2)和层粘连蛋白受体(laminin receptor,laminin-R)在胃癌中的表达与胃癌生物学行为的关系。方法采用免疫组化EnvisionTM法检测82例胃腺癌组织中MMP-2和laminin-R的表达情况,分析其与胃癌生物学行为的关系。结果 MMP-2和laminin-R在胃癌中的阳性表达率分别为62.2%和52.44%;MMP-2和laminin-R与患者年龄、性别、肿瘤发病部位、肿瘤大小和分级均不相关(P>0.05);MMP-2蛋白表达与浸润深度、TNM分期相关(P<0.01,P<0.01);laminin-R表达与胃癌浸润深度、淋巴结转移、TNM分期相关(P<0.01,P<0.05,P<0.01);MMP-2和laminin-R在胃癌中表达呈正相关关系(r=0.72)。结论胃癌组织中MMP-2与laminin-R表达参与胃癌的侵袭和淋巴结转移。
Objective To investigate the correlation between the expression of MMP-2,laminin receptor and the biological behavior of gastric carcinoma.Methods The expressions of MMP-2 and laminin receptor in 82 cases of gastric cancer were detected by EnvisionTM method.Results The positive rates of MMP-2 and laminin receptor in gastric cancer was 62.2% and 52.44% respectively.Patients＇ age,gender,tumor location,size and grade were not related to the expression of MMP-2 and laminin receptor（P 0.05）.The expression of MMP-2 was significantly related to depth of invasion（P 0.01） and TNM staging（P 0.01）.The expression of laminin receptor was significantly related to depth of invasion（P 0.01）,lymph node metastasis（P 0.05） and TNM staging（P 0.01）.The expression of MMP-2 and laminin receptor in gastric cancer was positive correlated（r = 0.72）.Conclusion The expression of MMP-2 and laminin receptor in gastric tissues is involved in the invasion and lymph node metastasis of gastric cancer.
出处
《实用医院临床杂志》
2010年第5期21-23,共3页
Practical Journal of Clinical Medicine
基金
贵州省科学技术基金资助项目[黔科合J字(2008)2278]
关键词
胃癌
基质金属蛋白酶-2
层粘连蛋白受体
生物学行为
Carcinoma of stomach
Matrix metalloproteinase-2
Laminin receptor
Biological behavior
