摘要
本文应用酶联免疫测定法对广西壮族自治区原发性肝癌高发的扶绥县和低发的阳朔县,进行了黄曲霉毒素B_1及代谢物黄曲霉毒素M_1和原发性肝癌关系的流行病调查。结果发现,原发性肝癌的死亡率与黄曲霉毒素B_1摄入量,晨尿黄曲霉毒素M_1排出量呈明显的正相关。展尿黄曲霉毒素M_1排出量可作为人群接触黄曲霉毒素B_1水平的指标。原发性肝癌死亡率与玉米、花生和花生油的摄入量有关。
The mortality rates from primary liver cancer in five groups of inhabitants from four villages were 125, 97.40, 42.65, 24.02 and 1.06 respectively. In the correspondiug groups, the medians of anatoxin Bj personal intakes were 6.05, 6.36, 2.69, 1.83 and 0 μg/day and the medians in morning urine of anatoxin M1 output were 16.46, 8, 29, 4.78 and 1.21 ng/persoa. Significant positive correlation also existed between the mortality rates of primary liver cancer and anatoxin intake. Analysis of anatoxin M1 in urine can be used as an index for human exposure of anatoxin B1 in an epidemiological study. Corn and peanut oil were the major sources of anatoxin B1. A strong correlation between intakes of corn, peanut, peanut oil and mortality rates of primary liver cancer were observed.
出处
《上海医科大学学报》
CSCD
1990年第2期153-156,共4页
Journal of Fudan University(Medical Science)
关键词
黄曲霉毒素
肝癌
流行病学
aflatoxin B1
Aflatoxir, M1
primary liver cancer
enzyme-linikcd immunosorbent assay
analysis of correlation
linear test
