摘要
通过药敏试验、联合抗菌作用试验、抗细菌感染试验及抗炎试验,对杨树花提取物及其复方制剂的药理作用进行了研究。结果显示,杨树花水提液及其复方制剂对大肠杆菌、沙门氏菌标准菌和致病菌有中度抑菌活性;杨树花水提液的乙酸乙酯及正丁醇萃取物对大肠杆菌标准菌和致病菌、沙门氏菌标准菌也有中度抑菌活性,但对沙门氏菌致病菌的抑菌活性较低,杨树花与黄芩联合抗菌具有相加作用。抗细菌感染及抗炎试验结果证实,杨树花水提液及复方制剂在昆明系小白鼠体内对大肠杆菌具有抑菌作用,高、低剂量杨树花水提液可使小鼠耳肿胀度明显降低,其抑制率分别为65.0%和51.6%。结果表明,杨树花提取物及其复方制剂具有明显的抑菌、抗炎作用。
Pharmacological effects of Populus tomentosa extracts and their compound preparations were studied in the drug sensitivity test,the combined antibacterial activity test,the antibacterial infection test and the anti-inflammatory effect test.In result,Populus tomentosa aqueous extract and the compound preparation had moderate antibacterial activity against four tested bacteria（pathogenic and standard strains of Escherichia coli and Salmonella）.Ethyl acetate and n-butanol extracts of the Populus tomentosa aqueous extract also had a moderate antibacterial activity against pathogenic and standard strains of E.coli and standard strains of Salmonella.In contrast,the antibacterial activity against the pathogenic Salmonella was low,and Populus tomentosa and Scutellaria baicalensis had additive effect on the antibacterial activity against E.coli.In the antibacterial infection and anti-inflammation tests,the Populus tomentosa aqueous extract and compound preparation had antibacterial activity against E.coli in vivo,and high and low dose groups of Populus tomentosa aqueous extract reduced the auricular swelling in Kunming mice,and the inhibition rates were 65.0% and 51.6%,respectively.The results showed that the Populus tomentosa aqueous extracts and their compound preparation possessed the significant antibacterial and anti-inflammatory effects.
出处
《中国兽医科学》
CAS
CSCD
北大核心
2010年第2期205-209,共5页
Chinese Veterinary Science
基金
教育部"长江学者和创新团队发展计划"创新团队项目(IRT0848)
关键词
杨树花
抑菌
抗炎
联合抗菌作用
Populus tomentosa
antibacteria
anti-inflammatory
combined antibacterial activity
