摘要
目的：在建立ＡＨＮＰ的大鼠模型基础上，初步研究急性胰腺炎（ＡＰ）的成因及药物对其的治疗作用。方法：利用微循环技术观察微血管口径、密度、血流速度、血流状态、微区血流量及治疗前后胰淀粉酶的变化及其光镜、电镜的超微病理学改变。结果：生长抑素十四肽组微循环各项指标的改善较模型组差异显著（Ｐ＜０．０１），胰腺病变程度显著轻于病理对照组。结论：胰腺微循环的障碍可导致ＡＰ的发生，而生长抑素十四肽能有效地改善胰腺微循环而达到治疗目的。
Objective: The purpose of the experiment was to investigate the pathogenesis of acute
pancreatitis(AP) and probe into the protective effects of drugs with an AP model in rats.
Methods: Pancreatic microcirculatory parameters were observed using intravital
microscopy,including the microvessel diameter,density,blood flow rate,flow state,blood flow
value of the microarea and the changes in pancreatic amylase before and after treatment.The
ultrastructural changes of pancreas were studied microscopically and with electromicroscopy.
Result:All the parameters studied in the group treated with somatosatin(SST) were improved
more markedly than those in animal models(P<0.01),and the pathological changes in the group
treated with SST were less than those in control group. Conclusion: The AP may be reduced by
microcirculatory disturbance and the latter may be improved by SST.
出处
《南京铁道医学院学报》
1999年第2期91-93,共3页
Journal of Nanjing Railway Medical College
基金
江苏省科委资助课题
