摘要
目的:探讨胃癌前病变病理改变的性质、程度和幽门螺杆菌(HP)感染及药物治疗与其变化过程的关系。方法:胃镜活检慢性萎缩性胃炎(萎缩)37例,伴肠上皮化生(肠化)19例、不典型增生7例,观察其与HP关系,HP以Gimesa染色,肠化者以粘液组织化学染色。19例萎缩伴肠化服德诺28d加施尔康6个月,HP阳性者加阿莫西林14d治疗,常规胃镜查HP根除率。随访6~31.5个月复查胃镜及HP。结果:萎缩、肠化、不典型增生HP阳性率分别为86.5%(32/37)、78.9%(15/19)和57.1%(4/7)。19例萎缩伴肠化HP根除率为66.7%(10/15),萎缩、炎症、肠化改善有效率分别为63.2%(12/19)、73.7%(14/19)和78.9%(15/19)。其中已根除HP者分别占66.7%(8/12)、71.4%(10/14)和66.7%(10/15),与未根除HP者炎症与肠化改善例数比较有显著性差异(P<0.01)。结论:胃癌前病变与HP关系密切,联合抗HP药物及多种维生素疗法对改善胃癌前病变有效。
bjective: The purpose of the study was to investigate the
relationship between gastric precancerous change and Helicobacter pylori (HP). Methods:
Thirtyseven patients with chronic atrophic gastritis(CAG),19 cases of CAG with intestinal
metaplasia(IM) and 7 cases with atypical hyperplasia were biopsyed by endoscopy to observe
their correlation with HP.The HP positive specimens were stained with Gimesa's dyeing, and
the sections from patients with IM were examined with mucus histochemistry dye.Ninteen
cases of CAG with IM were treated Denol for 28 days and TheragraM for 6 months.The HP(+)
cases were added with Amoxycillin remedy for 14 days.HP eradication was examined by
regular endoscopy.The patients were counterchecked by endoscopy and HP at the followup of
631.5 months. Results: The HP positive rate of patients with CAG,IM and atypical hyperplasia
was found to be 86.5%(32/37),78.9%(15/19) and 57.1%(4/7),respectively.The HP eradication in
19 cases of CAG with intestinal epidermis was detected in 10 of 15 (66.7%). The effective rate of
improvement of atrophy, inflammation and IM was found to be 63.2% (12/19), 73.7% (14/19) and
78.9%(15/19),respectively.The HP eradication rate was found to be 66.7%(8/12), 71.4%(10/14)
and 66.7%(10/15),respectively.These values are of significance(P<0.01) in comparison with
those from noneradication group. Conclusions: There is a close relationship between gastric
precancerous changes and HP.The combined therapy of antiHP drugs with multivitamins is
effective to improve gastric precancerous changes.
出处
《南京铁道医学院学报》
1999年第2期105-107,共3页
Journal of Nanjing Railway Medical College
基金
广州铁路集团公司科技发展计划
关键词
幽门螺杆菌
萎缩性胃炎
肠上皮化生
胃癌
Helicobacter pylori
chronic
atrophic gastritis
intestinal metaplasia
atypical hyperplasia