摘要
目的探讨环孢素A（CsA）联合激素治疗儿童紫癜性肾炎的临床疗效及意义。方法 35例紫癜性肾炎患儿入院后口服CsA,剂量为每天5-8 mg/kg,疗程3-6个月,同时联合激素治疗。治疗前及治疗后观察血、尿常规、24h尿蛋白定量、血浆白蛋白、血总胆固醇、尿沉渣红细胞计数、血肌酐（Cr）等指标。10例行肾活检,了解病理类型。结果 35例患儿经治疗后,完全缓解22例（62.86%）,缓解12例（34.28%）,无效1例（2.86%）。10例肾活检病理类型为肾小球轻微异常2例,系膜增生性肾小球肾炎7例,膜增生性肾小球肾炎1例。结论环孢素A联合激素能有效治疗儿童紫癜性肾炎,缩短病程。
Objective To investigate the clinical effectiveness and significance of treatment of purpura nephritis with ciclosporin A（CsA） and prednison in children.Methods CsA（5-8 mg/kg/day） and prednison were taken orally for 3-6 months in 35 hospitalized children cases of purpura nephritis.Blood and urine routines,24h urine protein,URBC and serum creatinine were examined before and after treatment.Renal biopsy was performed in 14 cases.Results After treatment,complete remission was achieved in 22（62.86%） patients,partial remission in 12（34.28%） patients and no remission in one（2.86%） patient.Of the 10 cases with renal biopsy,the pathological examination confirmed minimal change nephrosis in 2 cases,mesangial proliferative nephritis in 7 cases and mesangioproliferative glomerulonephritis in one case.Conclusion CsA and prednison can treat purpura nephritis effectively.
出处
《临床和实验医学杂志》
2010年第17期1294-1295,1297,共3页
Journal of Clinical and Experimental Medicine
关键词
儿童
紫癜性肾炎
环孢素
激素
Children
Purpura nephritis
Ciclosporin A（CsA）
Prednison
