摘要
目的探讨急性Ｇｕｉｌａｉｎ－Ｂａｒｅ综合征（ＧＢＳ）的免疫学改变及其与临床的关系。方法测定２１例急性期ＧＢＳ患者和１６例正常人血清及外周血单个核细胞（ＰＢＭＣ）上清液ＩＬ－２、ＩＬ－６、ＴＮＦ－α、免疫球蛋白及血清Ｔ细胞亚群。结果ＧＢＳ患者血清ＩＬ－２、ＴＮＦ－α，ＰＢＭＣ上清液ＩＬ－２、ＩＬ－６、ＴＮＦ－α和ＩｇＧ都高于正常对照组（Ｐ＜０．０５或０．０１）；１４例患者有一种以上血清免疫球蛋白或ＩｇＧ亚类增高；与对照组比较，患者ＣＤ３、ＣＤ４无异常，ＣＤ８降低（Ｐ＜０．０１），致ＣＤ４／ＣＤ８比值升高（Ｐ＜０．０１）。重型组ＰＢＭＣ上清液ＴＮＦ－α高于轻型组（Ｐ＜０．０５）。结论ＧＢＳ患者存在Ｔ细胞功能紊乱和Ｂ细胞多克隆活化，ＩＬ－２、免疫球蛋白、尤其ＴＮＦ－α异常在ＧＢＳ发病中起重要作用。
Objective To study the relationship between immunologic change and clinical status in the patients with acute Guillain Barre syndrome(GBS).Methods The T lymphocyte subset and the levels of interleukin(IL) 2,IL 6,tumor necrosis factor(TNF) α and IgG in the serum and supernatants of peripheral blood mononuclear cells(PBMCs) from 21 patients with GBS and 16 normal persons were measured. Results Compared with control group,the levels of serum IL 2,TNF α and supernatants IL 2,IL 6,TNF α and IgG were significantly higher in GBS group( P <0.05 or 0.01).The levels of TNF α in severe ca ses were higher than those in patients with mild symptoms. Serum IgG,IgA,IgM and IgG subclasses were elevated in 14 patients.The changes of CD 3 and CD 4 cell in the patients were not found to be different from those in the controls. The CD 8 cell was less( P <0.01) and the rate of CD 4/CD 8 cell was higher than those in the controls( P <0.01). Conclusion There were T cell immunity abnormality and polyclonal B cell activation in patients with GBS. IL 2,Ig,especially TNF α abnormality might play the important role in the pathogenesis of GBS.
出处
《临床神经病学杂志》
CAS
1999年第3期152-154,共3页
Journal of Clinical Neurology
