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铁元素与妊娠期糖尿病的相关性研究进展 被引量：6

Advancement in Correlation Study on Iron and Gestational Diabetes Mellitus
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摘要 铁是人体必需的微量元素,有着重要的生物学功能。母体适量充足的铁储备是维持正常妊娠的必要条件。近年研究发现,母体储存铁的升高与妊娠期糖尿病(GDM)的发病风险增高有关,是其独立危险因素;而缺铁性贫血可以降低GDM的发病率,是GDM的保护因素。由铁介导的氧化应激机制可能参与了GDM的发生与发展。 Iron is an essential nutrient with crucial biological function. Sufficient amount of maternal iron store is the necessary condition to maintain the normal pregnancy. Recent studies have suggested that elevated matemal iron store is an independent risk factor of gestational diabetes mellitus（GDM） ; while iron deficient anemia is a protective condition of GDM, which can reduce the incidence it. Increasing evidences suggest that oxidative stress related to high iron levels is the more likely mechanism that involved in the incidence and development of GDM.
作者 蒋静 程海东
机构地区 复旦大学附属妇产科医院
出处 《国际妇产科学杂志》 CAS 2010年第4期241-244,共4页 Journal of International Obstetrics and Gynecology
关键词 糖尿病 妊娠 铁蛋白质类 氧化性应激 炎症 Diabetes, gestational Ferritins Oxidative stress Inflammation
分类号 R714.2 [医药卫生—妇产科学]
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参考文献20

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同被引文献40

  • 1Yamauchhi T,Kamon J,Ito Y,et al.Cloning of adiponectin receptors that mediate antidiabetic metabolic effects[J]. N ature,2003,423(6941 ):762-769.
  • 2Bo S,Menato G,Villois P,et al.Iron supplementation and gesta tional diabetes inmidpregnancy[J].Am J ObstetGynecol,2009,201 (2):158.
  • 3Weinberg ED. Are iron supplements appropriate for iron replete pregnant women[J].Med Hypotheses,2009,73(5):714-715.
  • 4Lao TT,Ho LF,Chan BCP et al.Maternal age and prevalence of gestational diabetes mellitus[J].Diabetes Care,2006,29(4):948.
  • 5Cho NH. Gestationad diabetes mellitus-challenges in research and management [J]. Diabetes Res Clin Pract, 2013, 99 (2) :237-9.
  • 6Amiri FN, Basirat Z, Omidvar S, et al. Comparison of the serum iron, ferritin levels and total iron-binding capacity between pregnant women with and without gestational diabetes[J].J Nat Sci Biol Med,2013,4 (2) :302-5.
  • 7Afkhami-Ardekani M, Rashidi M. Iron status in women with and without gestational diabetes mellitus [J]. J Diabetes Complications, 2009,23 (3) :194-8.
  • 8Bo S, Menato G, Villois P, et al. Iron supplementation and gestational diabetes in midpregnancy [J]. Am J Obstet Gynecol, 2009,201 (2) :158.el-6.
  • 9Rajpathak SN, Crandall JP, Wylie-Rosett J, et al. The role of iron in type 2 diabetes in humans [J]. Biochim Biophys Acta, 2013,1790 (7) :671-81.
  • 10Femandez-Cao JC, Arija V, Aranda N, et al. Heme iron intake and risk of new-onset diabetes in a Mediterranean population at highrisk of cardiovascular disease :an observational cohort analysis[J]. BMC Public Health, 2013, 13:1042.

引证文献6

二级引证文献23

国际妇产科学杂志
2010年 第4期

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