摘要
目的:探讨中国苏南地区心脏机械瓣膜置换术后汉族人群细胞色素P450酶4F2(CYP4F2)基因rs2108622多态性对华法林剂量的影响,为以后利用基因多态性指导临床合理用药提供进一步理论依据。方法:采用碱基淬灭探针技术,检测197名心脏机械瓣膜置换术后患者的CYP4F2 rs2108622的基因型,分析与华法林剂量的相关性及影响。结果:CYP4F2 rs2108622基因多态性检测有115例CC型纯合子,73例CT型杂合子,9例TT型突变纯合子;等位基因频率为C 76.9%,T 23.1%;CC型患者华法林的平均稳定剂量为(2.51±0.82)mg.d-1,CT型为(2.74±0.96)mg.d-1,TT型为(3.20±1.22)mg.d-1,采用方差分析方法得到各组间华法林剂量差异P值小于0.05,有显著性差异。结论:在苏南地区心脏机械瓣膜置换术后汉族人群中,CYP4F2 rs2108622基因多态性与华法林剂量相关性有显著性差异,对华法林剂量有影响。
Objective：To investigate the association of CYP4F2 rs2108622 polymorphism with warfarin maintenance dose in the Han population of the south of Jiangsu province of Chinese.Methods：The single nucleotide polymorphism was detected by using a base-quenched probe technique.CYP4F2 rs2108622 polymorphisms were analyzed in 197 patients with mechanical heart valve replacement.Results：The genotypes of CYP4F2 rs2108622 showed that 115 patients were homozygous CC,73 were heterozygous CT,and 9 were homozygous TT genotype.The allelic frequency was C 76.9% and T 23.1%,respectively.The required warfarin dose for patients with the CYP4F2 rs2108622 genotype was CC（2.51±0.82） mg·d^-1,CT（2.74 ±0.96） mg·d^-1,and TT（3.20 ±1.22） mg·d^-1,respectively.Analysis of variance showed CYP4F2 rs2108622 was associated with warfarin dose.Conclusion：Our data shows that CYP4F2 rs2108622 is associated with the dose of warfarin in the Han population of the south of Jiangsu province.
出处
《药学与临床研究》
2010年第4期338-340,共3页
Pharmaceutical and Clinical Research
基金
江苏省卫生厅医药科技发展基金临床药学研究科技项目(P200804)
常州四药临床药学科研项目(CS2009901)
