期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

GHSR基因三个SNP位点与鸡生产性状的关联性分析 被引量：2

Analysis on associations of three SNP at Ghrelin receptor (GHSR) gene with chicken production traits
下载PDF
导出
摘要 根据已发表的鸡GHSR基因SNP位点,利用PCR-RFLP技术检测该基因C-1896A、C-1459T和A-1022C3个SNP位点在华南农业大学杏花鸡×隐性白洛克鸡全同胞F2代资源群体中的多态性,并构建单倍型,进行方差分析。结果表明,这3个SNP位点与其生长、屠体性状都不相关(P>0.05)。所构建的单倍型与单个SNP的分析结果一致,也与各生长、屠体性状都不相关(P>0.05)。表明这3个SNP不是鸡生长和屠体性状的重要分子标记。 According to the single nucleotide polymorphism （SNP） of Ghrelin receptor （GHSR） gene,the primers were designed for genotyping three SNP of GHSR gene （C-1896A,C-1459T and A-1022C）.These polymorphisms of GHSR gene were genotyped by PCRRFLP in a F2 full sib chicken population to investigate their associations with production traits.The results showed that no significant association of these three SNP with any growth and carcass traits was found （P0.05）.Association analysis of haplotypes indicated similar results with that of SNP.It was concluded that C-1896A,C-1459T and A-1022C of the GHSR gene were not important molecular markers for chicken growth and carcass traits.
作者 陈宇 方梅霞 徐海平 谢亮 张德祥 聂庆华
机构地区 华南农业大学动物科学学院 暨南大学医学院实验动物管理中心
出处 《广东农业科学》 CAS CSCD 北大核心 2010年第8期9-12,共4页 Guangdong Agricultural Sciences
基金 国家"863"重大专项(2010AA10A102)
关键词 鸡 GHSR基因 生长性状 屠体性状 关联分析 Chicken GHSR gene growth traits carcass traits association analysis
分类号 S831 [农业科学—畜牧学] Q789 [生物学—分子生物学]
  • 相关文献

参考文献25

  • 1Kojima M,Hosoda H,Date Y,et al.Ghrelin is a growth-hormone- releasing acylated peptide from stomach [J].Nature,1999,402 (6762): 656-660.
  • 2Seoane L M,Al Massadi O,Lage M,et al.Ghrelin: from a GH- secretagogue to the regulation of food intake, sleep and anxiety[J]. Pediatr Endocrinol Rev,2004(S3):432-437.
  • 3Hosoda H,Kojima M,Kangawa K.Biological, physiological, and pharmacological aspects of ghrelin [J].J Pharmacol Sci,2006,100(5): 398-410.
  • 4Sun Y,Butte N F,Garcia J M,et al.Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance[J].End ocrinology,2008,149(2):843 -50.
  • 5Shuto Y,Shibasaki T,Otagiri A,et al.Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding,and adiposity[J].J Clin Invest, 2002,109:1429-1436.
  • 6Zigman J M,Nakano Y,Coppari R,et aLMice lacking ghrelin receptors resist the development of diet-induced obesity[J].J Clin Invest2005,115: 3564-3572.
  • 7Howard A D,Feighner S D,Cully D F,et al. A receptor in pituitary and hypothalanms that functions in growth hormone release [J]. Science, 1996,273 (5277):974-977.
  • 8Miyasaka K,Hosoya H,Sekime A,et al.Association of ghrelin receptor gene polymorphism with bulimia nervosa in a Japanese population [J].J Neural Transal,2006, 113(9):1279-1285.
  • 9Wang H J,Geller F,Dempfle A,et al.Ghrelin receptor gene: identification of several sequence variants in extremely obese children and adolescents, healthy normal-weight and underweight students, and children with short normal stature [J].J Clin Endocrinol Metab,2004,89( 1): 157-162.
  • 10Pantel J,Legendre M,Cabrol S,et al.Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature [J].J Clin Invest, 2006316(3):760-768.

同被引文献19

  • 1SUN Y,BUTTE N F,GARCIA J M,et al.Charac-terization of adult ghrelin and ghrelin receptor knock-out mice under positive and negative energy balance[J].Endocrinology? 2008,149(2):843-850.
  • 2NIE Q,FANG M,XIE L,et al.Molecular charac-terization of the ghrelin and ghrelin receptor genesand effects on fat deposition in chicken and duck[J].Biomed Biotechnol,2009,2009:567120.
  • 3HOWARD A D,FEIGHNER S D,CULLY D F,etal.A receptor in pituitary and hypotha-lamus thatfunctions in growth hormone release[J].Science ,1996, 273:974-977.
  • 4ZHANG B,CHEN H,GUO Y,et al.Associationsof polymorphism within the GHSR gene with growthtraits in Nanyang cattle[J].Mol Biol Rep,2009,36(8):2259-2263.
  • 5SHUTO Y,SHIBASAKI T,OTAGIRI A,et al.Hypothalamic growth hormone secretagogue receptorregulates growth hormone secretion,feeding and adi-posity[J].J Clin Invest,2002,109 ; 1429-1436.
  • 6李敬瑞.猪五个候选基因的遗传变异研究[D].贵阳:贵州大学,2011.
  • 7LEI M,LUO C,PENG X,et al.Polymorphism ofgrowth-correlated genes associated with fatness andmuscle fiber traits in chickens[J].Poult Sci,2007,86(5):835-842.
  • 8PANTEL J,LEGENDRE M,CABROL S,et al.Loss of constitutive activity of the growth hormonesecretagogue receptor in familial short stature[J].JClin Invest,2006,116(3):760-768.
  • 9Sun Y,Butte N F,Garcia J M,et al.Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance[J].Endocrinology,2008,149(2):843-850.
  • 10Nie Q,Fang M,Xie L,et al.Molecular characterization of the ghrelin and ghrelin receptor genes and effects on fat deposition in chicken and duck[J].Journal of Biomedicine and Biotechnology,2009,2009:567120.

引证文献2

二级引证文献7

广东农业科学
2010年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部