摘要
采用硅胶柱预处理－ＨＰＬＣ对自制组曲Ｈ－１８及市售组曲中的洛伐他汀进行了定量分析， 线性范围 ０．６５～５７．２μｇ／ｍＬ，ｒ＝０．９９９９，加样回收率为９６．４％，ＲＳＤ＝３． ６８％。结果表明，各地产 红由商品药材中有 ７种洛伐他汀未测出或只有痕量，５种含量甚微（０．０８８～０．５５１μｇ／ｇ生药），而 自制组曲Ｈ－１８的洛伐他汀含量最高，达５μｇ／ｇ生药。
Hongqu, a well known TCM prepared by fermenting rice with Monascus purpureus Went (Monascaceae), used for the promotion of blood circulation and to resolve blood stasis, was speculated to contain some 'statins'. Pretreatment-HPLC is applied to determine lovastatin in Hongqu H-18 made in our own laboratory and some other commercially available Hongqu samples. The standard curve is linear in the concentration range of 0.65-57. 2μg/mL, the correlation coefficient is 0.9999. The average recovery rate is 96.4% and relative standard deviation 3.68% (n=5). The results showed that Hongqu from different commercial sources contain no or only a small amount of lovastatin (0.088-0.551μ/g), but amounted to almost 5 μ/g in Hongqu H-18
出处
《中草药》
CAS
CSCD
北大核心
1999年第2期100-102,共3页
Chinese Traditional and Herbal Drugs
