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磁共振扩散张量成像在颈髓病变中的应用 被引量:8

Clinical application of MR diffusion tensor imaging in cervical cord diseases
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摘要 目的:探讨磁共振扩散张量成像(DTI)技术在颈髓病变诊断中的临床应用。方法:应用1.5T磁共振机器对39例颈髓病变患者和15例健康志愿者行MRI常规和DTI检查,测定病变区和对照部位的FA值、ADC值并进行对照分析,并重建白质纤维束图。结果:健康志愿者颈髓的FA值为0.66±0.06,ADC值为(0.96±0.14)×10^-3mm^2/s。颈椎病病例FA值为0.47±0.05、ADC值为(1.16±0.28)×10^-3mm^2/s;与对照组统计学分析FA值明显降低(P〈0.01),ADC值明显增高(P〈0.01)。颈髓急性损伤病例FA值为0.38±0.08、ADC值为(0.89±0.25)×10^-3mm^2/s;与对照组统计学分析FA值明显降低(P〈0.01),ADC值与对照组无明显差异(P=0.130〉0.05)。颈髓炎症:FA值为0.40±0.06、ADC值为(1.25±0.40)×10^-3mm^2/s;与对照组统计学分析FA值明显降低(P〈0.01),ADC值明显增高(P〈0.01)。所有病例通过DTI技术成功显示了白质纤维束在病变区变形、移位及中断等改变。结论:DTI可以探测到颈髓病变中常规MR未能发现的病灶;白质纤维束成像可以显示白质束的受损情况。 Objective:To investigate the clinical application of MR diffusion tensor imaging (DTI) in cervical cord lesions.Methods:39 patients with clinical diagnosis and 15 healthy volunteers underwent MRI and DTI by using a 1.5T MR scanner.The values of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) were measured in both heathy subjects and patients,and the white matter fibertracts were performed in each patient.Results:The FA and ADC values of normal cervical cord were 0.66±0.06 and (0.96±0.14)×10^-3mm^2/s,the FA and ADC values of the patients with cervical spondylotic myelopathy (CSM) were 0.46±0.05 and (1.20±0.29)×10^-3mm^2/s,there was a statistically significant difference in the FA and ADC values between volunteers and CSM patients (P〈0.01).The FA and ADC values of the patients with acute cervical cord injury (CCI) were 0.38±0.08 and (0.89±0.25)×10^-3mm^2/s,the FA values between volunteers and CCI patients had statistically significant difference (P〈0.01),the ADC values had no statistically significant difference (P=0.075〉0.05).The FA and ADC values of the patients with the inflammatory disease of spinal cord were 0.40±0.06 and (0.96±0.14)×10^-3mm^2/s,there was a statistically significant difference in the FA and ADC values between volunteers and inflammatory disease of spinal cord.The fiber tracts showed the abnormal areas of the white matter,including displacement and interruption.Conclusion:DTI can detect the lesions of cervical cord,whereas T2WI findings were normal.Spinal cord fiber tracking can provide useful information for studying pathologic aspects on the cervical cord abnormalities.
出处 《放射学实践》 北大核心 2010年第8期834-838,共5页 Radiologic Practice
关键词 脊髓疾病 脊髓炎 磁共振成像 扩散张量成像 Spinal cord diseases Myelitis Magnetic resonance imaging Diffusion tensor imaging
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参考文献12

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同被引文献124

  • 1郑奎宏,马林,郭勇,郭行高,梁丽.多发性硬化颈髓扩散张量成像的初步研究[J].中国医学影像技术,2005,21(5):703-706. 被引量:6
  • 2郑奎宏,马林,郭勇,郭行高,梁丽.颈髓软化扩散张量成像的初步研究[J].中国医学影像技术,2005,21(7):1003-1005. 被引量:18
  • 3王霄英,谭可,倪石磊,鲍圣德,蒋学祥.用MR扩散张量成像评价犬急性脊髓损伤后神经前体细胞移植的作用[J].中华放射学杂志,2006,40(1):17-21. 被引量:30
  • 4郑奎宏,马林,郭行,高梁丽.正常人颈髓MR扩散张量成像的初步研究[J].中华放射学杂志,2006,40(5):490-493. 被引量:23
  • 5Schwartz ED, Shumsky JS, Wehrli S, et al. Ex vivo MR determined apparent diffusion coefficients correlate with motor recovery mediated by intraspinal transplants of fibroblasts genetically modified to express BDNF[ J]. Exp Neuro1,2003 ; 182 ( 1 ) :49 - 63.
  • 6Herrera JJ, Chacko T, Narayana PA. Histological Correalation of Diffusion Tensor Imaging Metrics in Experimental Spinal Cord Injury [ J ], J Neurosci Res, 2008,86 ( 2 ) : 443 -447.
  • 7Assaf Y, Pastemak O. Diffusion tensor imaging ( DTI )based white matter mapping in brain research: a review [J]. J Mol Neurosei ,2008 ,34 (1) : 51 -61.
  • 8Takahashi M, Hackney DB,Zhang G, et al. Magnetic resonance microimaging of intraxonal water diffusion in live excised lamprey spinal cord[ J]. Proc Natl Acad Sci USA. 2002 ;99 (25) : 16192 - 16196.
  • 9Ellingson BM, Kurpad SN, Schmit BD. Ex Vivo DiffusionTensor Imaging and Quantitative Tractography of the Rat Spinal Cord During Longterm Recovery From ModerateSpinal Contusion [ J ]. J Magn Reson Imaging, 2008 ; 28 (5) : 1068 - 1079.
  • 10WheelerKingshott CA, Hickman SJ, Parker GJ, et al. Investigating cervical spinal cord structure using axial diffusion tensor imaging [ J ]. Neuroimage, 2002 ; 16 ( 1 ) : 93 -102.

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