摘要
以2-甲硫基苯胺为原料,反应通过酰化、碘环化以及Suzuki交叉偶联反应,合成了2,5-二甲基-3-苯基-1,5-苯并硫氮杂卓-4(5H)-酮,该方法反应步骤少,产物立体选择性好,反应总收率为70.8%,产物结构经NMR和MS得以确证。
2,5-dimethyl-3-phenyl- 1,5-benzothiazepin-4（5H）-one（4） was synthesized through acylation, iodocyclization and Suzuki cross-coupling reaction using 2-（methylthio）aniline as the initial materials. The method had the advantages of fewer steps and good selectivity. The total yield of compound 4 was up to 70.8% and the structure was characterized by NMR and MS spectrum.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2010年第8期585-587,共3页
Chinese Journal of Antibiotics
基金
湖南省自然科学基金资助项目(08JJ3018)
湖南省教育厅资助项目(08C828)
