摘要
目的前瞻性比较药物流产与手术流产对再次妊娠孕期、围生期和新生儿并发症的影响。方法选取单活胎、头位未产妇300例,按既往早期妊娠终止方式将入选孕妇分为药物流产组(n=100)和手术流产组(n=100),无流产史者设为对照组(n=100),观察3组孕期、围产期及新生儿并发症发生情况。结果 3组先兆流产发生率差异有显著性(χ2=17.855,P<0.05),其中手术流产组发生率(25.0%)显著高于药物流产组(11.0%)和对照组(5.0%)(χ12=6.640,χ22=15.686,P<0.0125);3组胎盘粘连发生率差异有显著性(χ2=15.385,P<0.05),其中手术流产组发生率(18.0%)显著高于药物流产组(6.0%)和对照组(3.0%)(χ12=6.818,χ22=17.971,P<0.0125);3组胎盘残留发生率差异有显著性(χ2=8.143,P<0.05),手术流产组发生率(12.0%)高于对照组(2.0%)(χ2=7.680,P<0.0125);手术流产组产时出血量(166.5±18.2)mL高于药物流产组(143.8±17.3)mL和对照组(139.1±16.9)mL,(t1=2.394,t2=4.188,P<0.05)。手术流产≥2次组先兆流产率、胎盘粘连率、胎盘残留率和产时出血量均显著高于手术流产1次组(χ12=12.733,χ22=7.657,χ22=7.924,t=3.585,P<0.05),药物流产两亚组发生率差异无显著性(均P>0.05);除药物流产≥2次亚组先兆流产发生率(16.7%)高于对照组(χ2=5.204,P<0.05)之外,药物流产组与对照组其他并发症发生率均无差异(均P>0.05)。3组新生儿并发症发生率无差异(均P>0.05)。结论药物流产对再次妊娠的影响小于手术流产,两种流产次数越多,对再次妊娠的影响越大。
【Objective】To investigate the influence of medical abortion and surgical abortion on complications of subsequent pregnancy,perinatal period and neonate.【Methods】300 nullipara were selected and divided into medical-abortion group （n =100） and surgical-abortion group （n =100） according to the terminational style of former pregnancies,and 100 nullipara who had no abortion history was set as a control group.Complications of subsequent pregnancy,perinatal period and neonate were observed.【Results】There was statistically significant difference of threatened abortion rate among three groups （χ2=17.855,P 0.05）,threatened abortion rate of surgical-abortion group （25.0%） was much higher than medical-abortion group （11.0%） and control group （5.0%） （χ12=6.640,χ22=15.686,P 0.0125）;The placental adherence rate among three groups was statistically significant （χ2=15.385,P 0.05）,surgical-abortion group had the higher incidence rate （18.0%） than both medical-abortion group （6.0%） and control group （3.0%） （χ12=6.818,χ22=17.971,P 0.0125）;statistically significance was also found in placenta residue rate among three groups （χ2=8.143,P 0.05）,the rate of surgical-abortion group （12.0%） was higher than control group （2.0%）;Intrapartum hemorrhage of surgical-abortion group （166.5±18.2） mL was more than medical-abortion group （143.8±17.3） mL and control group （139.1±16.9） mL,（t1=2.394,t2=4.188,P 0.05）.The rate of threatened abortion,placental adherence,placenta residue and intrapartum hemorrhage of nullipara with surgical-abortion ≥2 times was significantly higher than those with one surgical abortion （χ12=12.733,χ22=7.657,χ22=7.924,t =3.585,P 0.05）,no statistical significance was found betwwen medical-abortion subgroups （all P 0.05）.There was no statistical significance between medical-abortion group and control group （all P 0.05） except the subgroup with medical-abortion ≥ 2 times had higher threatened abortion rate （16.7%） than control group.The incidence of neonate complications was not statistically significant among three groups （all P 0.05）.【Conclusion】The influence of medical abortion to subsequent pregnancy was less than surgical abortion,both with more frequency,more influence.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第15期2346-2349,共4页
China Journal of Modern Medicine
关键词
妊娠
药物流产
手术流产
并发症
pregnancy
medical abortion
surgical abortion
complications
