摘要
目的:探讨无创正压通气与纳洛酮联合治疗Ⅱ型呼吸衰竭并发肺性脑病的临床疗效。方法:56例患者随机分为2组,对照组28例给予常规药物治疗。治疗组28例在对照组的基础上加用无创正压通气同时加用纳洛酮0.4～0.8mg静脉推注,2次/d;2d为1疗程,共3个疗程,观察治疗前、后患者的临床表现、血气分析的变化。结果:2组比较,治疗组总有效率92.9%,对照组64.3%,差异有统计学意义(P(0.05)。治疗后治疗组PaO2、SpO2显著高于对照组(P<0.01),PaCO2显著低于对照组(P<0.01)。结论:无创正压通气与纳洛酮联用较单纯药物治疗能明显改善缺氧及二氧化碳潴留,更好的缓解临床症状。
Objective： To explore the therapeutic effect of noninvasive positive ventilation plus Naloxone in treatment of type II respiratory failure complicated with pulmonary encephalopathy. Methods： Fifty-six patients were randomly divided into 2 groups. Twenty-eight cases in control group received conventional medical therapy, and 28 cases in treatment group received noninvasive positive ventilation puls Naloxone 0. 4-0. 8 mg intrave nously based on the conventional therapy. Clinical manifestations and changes of arterial blood gas were observed before and after treatment. Results： The total efficacy rate of treatment group vs control group were 92. 9% vs 64. 3%, there was a significant difference among the two groups （P〈0. 05）. PaO2 and SpO2 were significantly higher after treatment in treatment group than those in control group, and PaCO2 was significantly lower in con trol group （P〈0. 01）. Conclusions： Combined use of noninvasive ventilation puls Naloxone can rapidly improve clinical symptoms and arterial blood gases.
出处
《内科急危重症杂志》
2010年第4期201-202,共2页
Journal of Critical Care In Internal Medicine
关键词
慢性肺源性心脏病
Ⅱ型呼吸衰竭
肺性脑病
无创通气
纳洛酮
Chronic pulmonary heart disease Type II respiratory failure Pulmonary encephalopathy Noninvasive ventilation Naloxone
