摘要
目的 观察尿激酶对血液透析患者动静脉内瘘血栓进行溶栓的疗效,探讨简单、安全、有效的溶栓方法.方法 回顾性分析本中心23例患者43例次局部注射尿激酶治疗动静脉内瘘血栓形成资料,比较溶栓前后的部分凝血活酶活化时间（APTT）、纤维蛋白原（Fbg）、国际标准化比值（INR）、凝血酶原时间（PT）、凝血酶时间（TT）.结果 23例患者共行43例次溶栓治疗,成功33例次占76.7%,未见不良反应.溶栓治疗与血栓形成的时间有关,与年龄、透析年限及内瘘使用时间无关,溶栓前后APTT、Fbg、INR、PT、TT差异无统计学意义.结论 尿激酶对动静脉内瘘溶栓治疗操作简单,创伤小,成功率较高,不良反应少,有较高的临床应用价值.
Objective To observe the effects of urokinase in the treatment of thrombosis in hemodialysis patients with arteriovenous fistulae and to discuss simple, safe and effective methods of thrombolysis. Methods Local injections of urokinase were applied in 23 hemodialysis patients for 43 times to treat thrombosis in fistula, then the effects were observed, and the changes between before treatment and after treatment of several index, such as activated partial thromboplastin time（ APTT）, Fibrinogen（ Fbg）, international normalized ratio （INR）, Prothrombin Time （PT）, thrombin time（TT） were compared. Results The thrombolytic therapies were used in 23 cases for 43 times in total, in which 33 times （76.7% ） received success, and there were no severe complications occurred. The effectiveness was related to the duration of thrombosis. There were no significant differences in comparison of APTT, Fbg, INR, PT, TT before and after urokinase administration. Conclusions Urokinase was effective in thrombolytic therapy for hemodialysis patients with thrombosis in arteriovenous fistula.
出处
《中华现代护理杂志》
2010年第22期2620-2622,共3页
Chinese Journal of Modern Nursing
关键词
尿激酶
动静脉内瘘
溶栓
血栓
护理
Hemodialysis
Arteriovenous fistulae
Thrombolysis
Thrombus
Nursing
