摘要
目的:研制甲基莲心碱脂质体,并对其体外性质进行考察。方法:采用薄膜分散法制备脂质体,利用正交实验对其处方进行优化对其形态、粒径、包封率及释药等体外性质进行考察。结果:甲基莲心碱脂质体形态规整,平均粒径为(842.5±4.65)nm,平均包封率为(72.8±1.5)%体外释药遵循Higuchi方程:Q=30.78t_(1/2)-5.12,(R^2=0.995),具有明显的缓释效果。结论:优化得到甲基莲心碱脂质体的处方及制备工艺,为进一步体内研究奠定了基础。
Objective： To study the preparation of neferine liposomes and drug release in vitro. Method： Neferine liposomes was prepared by film dispersion method. The formulation was screened by orthonogonal test and the appearance, mean size, encapsulation rate （ER%） and drug release in vitro were studied. Result： The shape of neferine liposomes was spherical with mean diameter of （842. 5 ±4. 65） nm and ER% of （72. 8 ± 1.5 ） %. Drug release rate was accorded with Higuchi equation of Q = 30. 78t1/2 - 5.12, （ R2 = 0. 995 ）, showed significant sustained release property. Conclusion： The optimal formulation and preparation process of neferine liposomes was the basis of further study in vivo.
出处
《中国药师》
CAS
2010年第9期1255-1257,共3页
China Pharmacist
关键词
甲基莲心碱
脂质体
制备
体外释药
Neferine
Lliposomes
Preparation
Drug release in vitro
