摘要
目的:建立复方磺胺嘧啶分散片中冰片的体外溶出度测定方法。方法:依据《中国药典》2005年版溶出度测定法,以水为溶出介质,转速75 r·min^(-1),45 min取样测定溶出度。结果:冰片在0.42～4.20μg浓度范围内与峰面积呈良好的线性关系(r=0.999 7),回收率98.8%(RSD=0.8%);3批样品在45 min的平均溶出量均在88.6%以上。结论:该法稳定、简便、准确,可用于复方磺胺嘧啶分散片中冰片的体外溶出度测定。
Objective： To esteblish the determination method of dissolution of borneol from compound sulfadiazine dispersible tablets in vitro. Method： Pure water was taken as the solvent with the rate of rotation 75 r.min^-1, and the sampling time was 45 min. The dissolution of compound sulfadiazine dispersible tablets was determined in accordance with the third appendix of Chinese Parmacopoeia of 2005 Edition. Result： The linear range of borneol was 0. 42-4. 20 μg .（ r = 0. 999 7）, the average recovery rate was 9.8.76% （ RSD = 0. 8% ）. The mean cumulative dissolution of three batches of dispersible tablets was above 88. 6%. Conclusion： The method is simple, accurate, reliable, and can be used to determine the dissolution of this preparation.
出处
《中国药师》
CAS
2010年第9期1293-1295,共3页
China Pharmacist
基金
郑阳医学院研究生启动基金资助项目(编号:2007QDJ3)
关键词
复方磺胺嘧啶分散片
冰片
溶出度
Compound sulfadiazine dispersible tablets
Borneot
Dissolution
