摘要
目的：测定甲状腺正常组织及良性结节的雌、孕激素受体表达，以了解甲状腺疾病与雌、孕激素的关系。方法：以葡聚糖活性碳饱和分析法测试人正常甲状腺组织２０例良性结节各１０例及其雌、孕激素受体的表达。结果：（１）人正常甲状腺组织中雌、孕激素受体分别有６例（６／２０）、７例（７／２０）阳性表达；（２）甲状腺腺瘤的雌、孕激素受体的表达分别有５例（５／１０）、６例（６／１０）；（３）结节性甲状腺肿的雌、孕激素受体表达分别有５例（５／１０）、６例（６／１０）。结论：甲状腺良性结节的发生发展过程与雌、孕激素有关，对女性或孕期妇女易罹患甲状腺疾病这一现象可做出一定的解释。
Objective: To evaluate the estrogen receptor (ER) and progesterone receptor (PR) expressions in normal and benign nodules of the thyroid. Methods: Normal and benign nodular thyroid samples were assayed for ER and PR with Dextran Carbo Activatus Saturation Analysis. Results: ER and PR expressions are present in 6(6/20) and 7(7/20) in normal thyroid tissues respectively; in 5(5/10) and 6(6/10) in thyroid adenoma, respectively and in 5(5/10) and 6(6/10) in nodules of goiter, respectively. Conclusion: ER and PR expressions are present in normal tissues and benign nodules of the thyroid. This may partly explain why the female is susceptible to thyroid diseases.
出处
《北京医科大学学报》
CSCD
1999年第1期88-89,共2页
Journal of Peking University(Health Sciences)
关键词
甲状腺肿
结节性
受体
雌激素
孕激素
Goiter, nodular Receptors, estrogen/metab Receptors, progesterone/metab
