摘要
目的:探讨燃煤型氟中毒地区人群过氧化氢酶(CAT)、谷胱甘肽S-转移酶(GSTs)活力与氧化应激的关系。方法:于贵州省毕节市鸭池镇燃煤型氟中毒非改灶村抽取245名村民作为非干预组,于该市长春镇燃煤型氟中毒改灶村抽取240名村民作为干预组,于非地方性氟中毒长顺县白云山镇抽取247名村民作对照组,利用比色法分别测定CAT、GSTs的活力。结果:非干预组血浆CAT活力和GSTs活力低于干预组和对照组,干预组低于对照组,各组间差异有统计学意义(P<0.05);各组间CAT、GSTs活力无性别差异(P>0.05)。结论:过量氟可能使体内自由基代谢失衡,推测通过人为干预氟的摄入,有助于机体恢复氧化平衡。
Objective： To investigate the relationship of plasma catalase（CAT） and glutathione S-transferase（GSTs） activity levels with oxidation stress in patients with coal-burning caused fluorosis.Methods： 245 villagers that use unchanged stoves in coal-burning fluorosis area were selected as non-intervention group（group N）,240 villagers using improved stoves in fluorosis endemic area were chosen as intervention group（group I）,and 247 villagers in non-fluorosis-endemic area were as control group（group C）.The activities of CAT and GSTs of them were tested with Spectrophotometer.Results： The activities of plasma CAT and GSTs of group N were significantly lower than those of group I（P0.05）,and the latter ones were significantly lower than those of group C（P0.05）.No significant difference of the two enzymes based on sex was found in all the 3 groups.Conclusion： Excessive intaking of fluorin might cause unbalance of free radical metabolism,and artificial intervention of fluorin intaking could help to recover the balance of oxidation.
出处
《贵阳医学院学报》
CAS
2010年第4期331-333,共3页
Journal of Guiyang Medical College
基金
国家科技部国际合作项目(2010DFB30530)
国家自然科学基金资助项目(30760224)
贵州省长专项资金资助项目(黔省专合字200980)
