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MINE方案治疗老年复发性侵袭性非霍奇金淋巴瘤的临床观察 被引量:4

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摘要 目的:目前对于老年复发性侵袭性非霍奇金淋巴瘤(non-Hodgkin′s lymphoma,NHL)尚无标准解救化疗方案,本文旨在探讨MINE方案(异环磷酞胺、美司钠、米托蒽醌及VP-16)治疗老年复发性侵袭性恶性NHL的疗效和不良反应。方法:17例老年复发性侵袭性NHL患者,既往均接受过2~6个周期的CHOP方案化疗复发或进展。现采用MINE方案化疗,中位疗程数4个周期(2~8个周期),所有患者均可评价疗效和不良反应。对患者进行解救治疗,并对毒副反应加以评估、预防及治疗。结果:17例患者MINE方案化疗后,总有效率为47.0%,完全缓解率为17.6%;T、B细胞NHL有效率分别为37.5%和45.5%,完全缓解率分别为12.5%和18.2%(P>0.05)。经MINE方案治疗的患者,骨髓抑制、消化系统反应、脱发是较常见的并发症,经过治疗均恢复,无治疗相关死亡。结论:MINE方案治疗老年复发性侵袭性NHL有效。
出处 《实用医学杂志》 CAS 北大核心 2010年第18期3410-3411,共2页 The Journal of Practical Medicine
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参考文献3

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共引文献10

同被引文献20

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