摘要
注意缺陷多动障碍（ａｔｅｎｔｉｏｎｄｅｆｉｃｉｔｈｙｐｅｒｃａｔｉｖｉｔｙｄｉｓｏｒｄｅｒ，ＡＤＨＤ）是常见的儿童行为障碍，目前病因尚未明确。国外近年由于分子生物学方法的介入，发现多巴胺Ｄ２受体ＴａｑＩＡ１等位基因与本病相关。通过对广州市城镇学龄儿童多巴胺Ｄ２受体基因ＴａｑＩＡ多态性的检测，支持Ａ１等位基因与本病的关系（Ｐ＝０．００６５２０）；并发现该基因与中医辨证的“肾虚肝亢”证候关系更为密切（Ｐ＝０．０００１２２），而“心脾不足”证候则与正常对照组间无显著性差异（Ｐ＝０．９１０９５２），因而在基因水平上为ＡＤＨＤ的中医辨证提供了参考思路。
Attention deficit hyperactivity disorder(ADHD)is a common behavior disorder in children and its pathogenesis remains unknown.It has been reported in foreign literature that the A 1 allele of the Taq I polymorphism of the dopamine D 2 receptor gene(DRD 2)was related to ADHD.In this study,the school_age children were examined by the above technique,and the results supported the relationship between the allelic gene and ADHD(P=0.006520),especially those with the syndrome of kidney deficiency and liver hyperactivity(P=0.000122)while not related to those with the syndrome of deficiency of heart and spleen(P=0.910952).This may supply a genetic basis for the syndrome differentiation of ADHD in TCM.
出处
《广州中医药大学学报》
CAS
1999年第1期17-20,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
广东省中医药管理局资助
关键词
注意缺陷
多动障碍
多巴胺D2受体
TaqIA
症候
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY/physiopathol.
RECEPTOR
DOPAMINE D 2
HEART_SPLEEN DEFICIENCY/pathogen(tcm)
KIDNEY DEFICIENCY FIRE/pathogen(tcm)
CHILD
