摘要
目的 测定全麻病人接受术前用药后异丙酚的诱导剂量。方法 选择择期手术病人９０例，随机分为６个异丙酚剂量组，每组１５例。诱导前３０ 分钟给予哌替啶５０ｍ ｇ，阿托品０５ｍ ｇ，诱导前用药为氟哌啶醇１ｍ ｇ，芬太尼１μｇ／ｋｇ。将唤之不能睁眼作为麻醉的最终效应点。得出剂量效应回归曲线。结果 异丙酚的ＥＤ５０ 和ＥＤ９０ 分别为０６７ｍ ｇ／ｋｇ（０．５９～０．７６ｍ ｇ／ｋｇ）和１．１１ｍ ｇ／ｋｇ（０．９８～１．２５ｍ ｇ／ｋｇ）。结论 应用术前药后，异丙酚的诱导用药剂量为１３４ｍ ｇ／ｋｇ（１．１８～１．５２ｍ ｇ／ｋｇ）
Objective To determine the dose of propofol for induction of anesthesia in premedicated adult patient.Methods Ninety patients with ASA grade Ⅰ Ⅱ,for elective surgery,were randomly divided into six groups by the predetermined dose of propofol(n=15,each group).Induction started after approximately 30 min premedication with intramuscula pethidine 50mg,atropine 0.5mg,haloperidol and fentanly were injected intravenously first,5min later propofol was administered.The abolition of the ability to open eyes on command was used as an end point of anesthesia.The dose response curve was determined with probit analysis.Results The ED 50 and ED 90 of propofol for induction with premedication were 0.67mg/kg (0.59 0.76mg/kg) and 1.11mg/kg(0.98 1.25mg/kg).Conclusion After administration of premedication and preinduction agents,the proper dose of propofol for induction anesthesia is 1 34mg/kg(1.18 1.52mg/kg).
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1999年第4期212-214,共3页
Chinese Journal of Anesthesiology
