摘要
目的 研究一氧化氮（ＮＯ）在缺血性急性肾衰竭病理过程中的作用。方法 通过夹闭大鼠双侧肾蒂４５分钟后再松夹复制出急性肾衰（ＡＲＦ）模型。各组在松夹后分别静滴生理盐水、Ｌ精氨酸、Ｄ精氨酸、Ｎ硝基Ｌ精氨酸（ＮＬＡ）。结果 与盐水对照组相比，Ｌ精氨酸组菊糖清除率和再灌注早期的尿流率增高（Ｐ＜ ００５），尿钠排泄分数下降（Ｐ＜ ００５），肾病理损害也较轻（Ｐ＜ ００５）。ＮＬＡ虽升高血压（Ｐ＜ ００１），但菊糖清除率反而降低（Ｐ＜ ００１）。Ｄ精氨酸组与对照组相比无差异。结论 Ｌ精氨酸通过增加ＮＯ的生成。
Objective To study the effects of nitric oxide (NO) on acute renal failure (ARF) induced by ischemia reperfusion in rats Methods ARF model was produced by clamping both renal pedicals 45min followed by releasing clamps These rats recieved saline,L arginine (300mg/kg),D arginine (300mg/kg),N nitro L arginine (NLA,10mg/kg) respectively after releasing clamps Results After L arginine administration inulin clearance and urine flow rate increased(P<0 05),fractional sodium excretion decreased(P<0 05), and renal physiological damage was attenuated (P<0 05), when compared with those after saline administration Although NLA remarkably increased mean arterial pressure (P<0 01),inulin clearance significantly diminished (P<0 01) There were not statistical differences in the above parameters between D arginine group and saline group Conclusion In early stage of ARF induced by ischemia reperfusion in rats,L arginine derived NO is capable of improving suppressed renal function and attenuating renal tissue damage,whereas NO synthase inhibitor NLA exagerate kidneys injurys
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1999年第4期245-247,共3页
Chinese Journal of Anesthesiology
