摘要
目的：探讨血液透析对老年尿毒症患者体液免疫和细胞免疫功能的影响。方法：对１００例老年尿毒症患者在血液透析前后采用琼脂单向扩散（ＳＲＩＤ）法和碱性磷酸酶抗碱性磷酸酶（ＡＰＡＡＰ）法进行了免疫球蛋白、Ｔ淋巴细胞亚群和自然杀伤（ＮＫ）细胞测定。结果：血透后ＩｇＡ〔（１．６９１±１．０８７）ｇ／Ｌ〕、ＩｇＭ〔（１．５９１±０．８６５）ｇ／Ｌ〕、ＣＤ＋３（６６．７０％±１０．１７％）、ＣＤ＋４（３９．５０％±９．１０％）、ＣＤ＋４／ＣＤ＋８比值（１．７０±０．２２）、ＮＫ细胞（５．９１％±１．６７％）均较血透前显著升高〔上述指标分别为（１．２８３±１．０９８）ｇ／Ｌ、（１．２８７±０．６８７）ｇ／Ｌ、５２．７０％±９．１６％、２９．３０％±９．４０％、１．２０±０．２０和４．３７％±１．５７％，Ｐ均＜０．０５〕，尤以ＩｇＧ升高显著〔（１２．２７０±３．９０３）ｇ／Ｌ比（９．９７３±３．１３３）ｇ／Ｌ，Ｐ＜０．０１〕。结论：充分血液透析可以改善老年尿毒症患者的免疫功能。
Objective:To investigate the effect of hemodialysis on humoral and cellular immune function in senile patients.Methods:Levels of serum immunoglobulin and T lymphocyte subpopulation were respectively determined by single radial immunodiffusion (SRID) and alkaline phosphateanti alkaline phosphate (APAAP) methods in uremic patients preand postdialysis.Results:After dialysis,levels of IgA (1 691±1 087)g/L ,IgM (1 591±0 865)g/L ,CD + 3(66 70%±10 17%),CD + 4(39 50%±9 10%),CD + 4/CD + 8 ratio (1 70±0 22)and NK cell (5 91%±1 67%) were higher than those prior to dialysis (1 283±1 098)g/L,(1 287±0 687)g/L ,52 70%±9 16%,29 30%±9 40%,1 20±0 20,and 4 37%±1 57%,respectively,all P <0 05 .Moreover,IgG was particularly elevated after dialysis (12 270±3 903)g/L vs.(9 973± 3 133)g/L, P <0 01 . Conclusions:The results indicate that adequate hemodialysis may improve the immune function in senile uremic patients.
出处
《中国危重病急救医学》
CAS
CSCD
1999年第4期215-216,共2页
Chinese Critical Care Medicine
关键词
尿毒症
血液透析
细胞免疫
体液免疫
治疗
uremia\ \ hemodialysis\ \ cellular immunity\ \ humoral immunity
