摘要
目的研究联合使用二氧化碳激光和咪喹莫特治疗尖锐湿疣的复发情况,与局部和血清细胞因子肿瘤坏死因子-α(TNF-α)改变的关系,探讨联合治疗后复发产生的部分机制。方法联合使用二氧化碳激光和咪喹莫特治疗尖锐湿疣。根据疗效分为治疗有效组和治疗后复发组,每组各30例。收集治疗前病理及血清标本,病理标本用免疫组织化学法标记TNF-α,血清标本用酶联免疫吸附试验(ELISA)检测TNF-α的含量,并探讨其相互关系。结果联合治疗后复发病人局部表皮中的TNF-α表达弱,血清中TNF-α表达亦弱,两者表现出了较强的相关性。结论联合治疗后复发病人局部皮肤中及血清中的TNF-α降低,可能与其复发机制有关。
Objective To assess the cytokine levels of TNF-α in the serum and pathological specimens of patients with recurrent condyloma acuminatum after treatment of CO2 laser and 5% imiquimod cream,and investigate its role in the mechanism of recurrent condyloma acuminatum.Methods CO2 laser and 5% imiquimod cream were used in patients with condyloma acuminatum simultaneously.According to the curative effect,the patients were divided into two groups：efficacy group and recurrent group.Each group had 30 patients.The pathological specimens were obtained before therapy and were marked by TNF-α with immunohistochemistry.ELISA was used to the serum for the TNF-α level.Results The TNF-α expression in the recurrent group was weaker than that in the efficacy group,both in the pathological and serum specimens.Conclusions Low level of TNF-α may be an important cause of recurrent condyloma acuminatum after treatment of CO2 laser and 5% imiquimod cream.
出处
《中国艾滋病性病》
CAS
2010年第4期393-395,共3页
Chinese Journal of Aids & STD
