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组蛋白修饰在糖尿病发病中的作用 被引量：2

Role of histone modification in the pathogenesis of diabetes
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摘要 组蛋白修饰是表观遗传学的一个重要内容,在基因表达调控中发挥至关重要的作用。最新研究表明组蛋白修饰直接或间接参与糖尿病的发病,深入研究糖尿病组蛋白修饰情况,将为糖尿病的治疗或干预带来全新的方法。 Histone modification is a very important part of epigenetics with a vital role in gene regulation.Recent studies have demonstrated that histone modification directly or indirectly contributes to the pathogenesis of diabetes,suggesting the potential role and therapeutic promise of histone modification in diabetes.
作者 刘细玉 侯粲 周智广
机构地区 中南大学湘雅二医院内分泌科中南大学代谢内分泌研究所
出处 《国际病理科学与临床杂志》 CAS 2010年第4期309-312,共4页 Journal of International Pathology and Clinical Medicine
基金 国家重点基础研究发展计划(973)(2009CB825605 2006CB503901)~~
关键词 组蛋白修饰 糖尿病 甲基化 乙酰化 histone modification diabetes methylation acetylation
分类号 R587.1 [医药卫生—内分泌]
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参考文献28

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同被引文献40

  • 1刘飞,靳飞,翟晓巧,贾峰.组蛋白甲基化和去甲基化研究进展[J].中国农学通报,2007,23(2):56-59. 被引量：4
  • 2张垚,李林鲜,李悦恒,李惠.胰岛素受体底物家族与Ⅱ型糖尿病关系性的研究进展[J].现代生物医学进展,2007,7(2):312-315. 被引量：9
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  • 8Mackenzie I R, Bigio E H, Ince P G, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations [J]. Ann Neurol, 2007, 61( 5 ) :427-434.
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国际病理科学与临床杂志
2010年 第4期

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