摘要
结直肠癌术后复发与转移的比例较高,且缺乏有效的预防手段与治疗方法。围手术期机体炎症功能的改变和手术应激与肿瘤预后密切相关,其中结直肠肿瘤环氧化酶-2(Cyc looxygenase-2)过度表达在患者免疫功能的转变上发挥了重要的作用。通过调节围手术期患者的免疫状态,控制外科应激,可能成为预防降低术后复发与改善预后的新途径。
There is a high proportion of recurrence and metastasis in postoperative colorectal patients.Moreover,no effective prevention or treatment approach has been found.In preoperative period,both the change of systematic inflammation response and surgical stress has been confirmed to associate with cancer prognosis.The over-expression of cyclooxygenase-2 plays an important role in the change of systematic immune function.By means of regulating the patients' immune response and controlling the surgical stress,the lower recurrence and improved prognosis may be approached.
出处
《临床肿瘤学杂志》
CAS
2010年第8期755-758,共4页
Chinese Clinical Oncology
关键词
结直肠肿瘤
炎症反应
围手术期
Colorectal neoplasms
Inflammation
Perioperative period
