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纳米颗粒抗菌机理的研究进展 被引量：18

Progress of Antibacterial Mechanisms Study on Nanoparticles
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摘要 随着具有抗菌效应的纳米颗粒被大量报道,纳米颗粒的抑菌杀菌机理也成为重要的研究领域并取得一定进展,本文综述了常见纳米颗粒作用机理的研究进展。当前大多数实验表明,纳米颗粒引起细胞膜的破坏是其抗菌抑菌效应的主要原因,结合已有研究,作者提出,纳米颗粒抑菌杀菌分为四个阶段：同细胞的接触、与细胞膜的相互作用及对膜的破坏、胞内杀菌和细菌死亡。文中重点分析探讨了纳米颗粒同细菌细胞膜作用过程中一些待解答的基础性问题。最后通过比较发现,纳米颗粒同抗生素作用方式相异,而与抗菌肽的作用模式相近,细菌对纳米颗粒较难产生耐药性,这对当前治疗耐药菌株的感染有良好的前景。 An explosive number of reports on antimicrobial nanoparticles has not yet translate into a comprehensive understanding of how these materials affect bacteria at the molecular level of.This review aims to summarize some of these antibacterial mechanisms.We propose that contacts,nanoparticlesmediated disruption of bacterial membranes,interactions between NPs and bacterial components within the membrane and bacteria death,are generally necessary steps in this process.We compare the differences of actions between nanoparticles,antibiotics and antimicrobial peptides.
作者 马万顺 崔燕 赵玉云 郑文富 张伟 蒋兴宇 张文杰
机构地区 北京林业大学理学院 国家纳米科学中心 东南大学
出处 《生物物理学报》 CAS CSCD 北大核心 2010年第8期638-648,共11页 Acta Biophysica Sinica
基金 国家自然科学基金项目(90813032) 国家重大科学研究计划基金项目(2009CB930001)~~
关键词 纳米颗粒 抗菌机理 抗生素 抗菌肽 Nanoparticles Antibacterial mechanisms Antibiotics Antibacterial peptides
分类号 R318.08 [医药卫生—生物医学工程] Q939.92 [生物学—微生物学]
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参考文献41

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二级参考文献49

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共引文献32

同被引文献260

引证文献18

二级引证文献116

生物物理学报
2010年 第8期

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