期刊文献+

a1b干扰素联合利巴韦林治疗老年慢性丙型肝炎36例临床观察 被引量:1

原文传递
导出
摘要 目的观察a1b干扰素联合利巴韦林治疗老年慢性丙型肝炎的疗效和药物不良反应。方法将接受a1b干扰素联合利巴韦林治疗的老年慢性丙型肝炎患者,和无意愿不接受该方案治疗的老年慢性丙型肝炎患者分为两组,治疗组36例和对照组34例,分别进行治疗后疗效及药物不良反应分析。结果36例治疗组EVR29例(80.6%)、ETVR22例(61.1%)、pETVR8例(22.2%)、NR6例(16.7%)、Relapse7例(31.8%),34例对照组EVR10例(29.4%),ETVR4例(11.8%)、pETVR6例(17.6%)、NR24例(70.6%)、Relapse3例(75%)两组比较,差异具有统计学意义(P〈0.05)。治疗组药物不良反应主要表现为流感样症候群、一过性骨髓抑制及胃肠道不适,均经对症处置后完成治疗。结论a1b干扰素联合利巴韦林对老年慢性丙型肝炎的治疗是安全、有效的。
出处 《中国临床实用医学》 2010年第9期136-137,共2页 China Clinical Practical Medicine
  • 相关文献

参考文献7

二级参考文献39

  • 1蔡雄,王国俊,瞿瑶,樊成辉,张瑞祺,徐文胜.苦参素注射液治疗慢性乙型肝炎临床疗效分析[J].第二军医大学学报,1997,18(1):47-49. 被引量:345
  • 2Ghany MG, Strader DB, Thomas DL, et al. Diagnosis, management, and treatment of hepatitis C: an update[J]. Hepatology, 2009,49(4): 1335-1374.
  • 3McCaughan GW, Omata M, Amarapurkar D, et al. Asian Pacific Association for the Study of the Liver consensus statements on the diagnosis, management and treatment of hepatitis C virus infection[J]. J Gastroenterol Hepatol,2007,22(5): 615-633.
  • 4Gordon SC. Treatment of viral hepatitis-2001 [J]. Ann Med, 2001,33(6):385-390.
  • 5Pawlotsky JM. Treating hepatitis C in "difficult-to-treat" patients[J]. N Engl J Med, 2004,351 (5):422-423.
  • 6Fried MW, Jensen DM, Rodriguez-Torres M, et al. Improved outcomes in patients with hepatitis C with difficult-to-treat characteristics: randomized study of higher doses of peginterferon alpha-2a and ribavirin[J]. Hepatology,2008,48(4): 1033-1043.
  • 7Alberti A. What are the comorbidities influencing the management of patients and the response to therapy in chronic hepatitis C? [J]. Liver Int,2009,29(Suppl 1):S15-S18.
  • 8Farnik H, Mihm U ,Zeuzem S. Optimal therapy in genotype 1 patients[J]. Liver Int, 2009,29(Suppl 1):S23-S30.
  • 9Poynard T, Colombo M, Bruix J, et al. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy[J]. Gastroenterology, 2009, 136(5):1618-1628.
  • 10Jensen DM, Marcellin P, Freilich B, et al. Re-treatment of patients with chronic hepatitis C who do not respond to peginterferon-alpha 2b: a randomized trial[J]. Ann Intern Med, 2009,150(8):528-540.

共引文献777

同被引文献7

引证文献1

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部