摘要
为了探讨去势对不同月龄雌性大鼠体质量、骨密度、组织病理学的影响，以便选用恰当月龄的大鼠复制绝经后骨质疏松的动物模型。本研究选用3、6、12月龄的SD雌性大鼠共48只，每月龄组16只，均分成A、B两组，A组为对照组，B组为去势组。分别于术后6、12周测量体质量、腰椎和股骨的骨密度及组织病理学观察。结果发现3月龄的去势级大鼠的体质量增加尤为明显，3、6月龄大鼠的去势组较对照组在去势后6、12周骨密度均有显著性差异（P＜0．001），组织病理学观察去势组骨小梁稀疏，皮质骨变薄，骨髓腔扩大；而12月龄的大鼠骨密度改变不显著。结论：绝经后骨质疏松模型复制大鼠的年龄是6月龄为佳，3～6月龄亦可选用，12月龄以后不适宜选择。
In order to evaluate the effect of ovariectomy on bone loss in differential age rat. 48 female SD rats well allocated randomly into three groups. Each group was divided into A、B. Group A was control and group B with ovary resected. 6 and 12 weeks after operation, weight, BMD of lumbar、femur and microdensitometrical analysis were made. Rusults revealed weight-increase obviously in 3-month-rats compared to other two groups (P<0.001).BMD in group B of 3 and 6-month-decreased obviously compared to group A. In group B of 3 and 6 month rats,lumbar trabecualare became decreasing and femur cortical got thinning. Whereas group A and group B in 12-monthrats, they had no significant difference. Conclusion, the effects of ovariectomy on bone loss in 3 and 6 monthly rats have obviously observed. As a model, six month rat is a good choice.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1999年第3期203-205,共3页
Journal of Nanjing Medical University(Natural Sciences)
