摘要
目的探讨阿立哌唑对男性精神分裂症患者泌乳素及血糖、体重的影响。方法将83例男性精神分裂症患者随机分为研究组(41例,阿立哌唑治疗)和对照组(42例,利培酮治疗),共治疗12周,基线时、治疗后第4周末、治疗后第8周末及治疗后第12周末应用阳性与阴性症状量表(PANSS)和副反应量表(TESS)分别评定疗效及安全性,并进行泌乳素、血糖、体重、BMI的测定。结果研究组和对照组在治疗后第4周末、第8周末及第12周末的PANSS各因子分及总分均低于基线时,差异均具有显著性意义(P<0.05)。在治疗各阶段,研究组的泌乳素、血糖、体重、BMI水平较基线时均无显著性改变(P>0.05),而在对照组中,治疗后各阶段的泌乳素、血糖、体重、BMI的水平较基线时均有不同程度的增加,且差异均具有显著性意义(P<0.05)。研究组的不良反应与对照组相当,均未见严重不良反应。结论阿立哌唑可有效改善男性精神分裂症患者的精神症状,且对泌乳素及血糖、体重无明显影响。
Objective To explore effects of aripiprazole on serum prolactin, blood sugar and body weight of male patients with schizophrenia. Methods A total of 83 male patients with schizophrenia were randomly divided into study group with aripiprazole and control group with risperidone for the treatment of 12 weeks. They were assessed with Positive and Negative Symptoms Scales （PANSS）, Treatment Emergent Side Effect Scale （TESS）, serum prolactin, blood sugar, body weight and Body Mass Index （BMI） in baseline, 4th weekend , 8th weekend and 12th weekend after treatment. Results The total and factors scores of PANSS in two groups on the 4th weekend , 8th weekend and 12th week- end after treatment were all significantly lower than those baseline（ P 〈 0.05 ）. On the 4th weekend , 8th weekend and 12th weekend, the levels of serum prolactin, blood sugar, body weight and BMI in study group had no significant differences with that in baseline（ P 〉 0.05 ）, while those control group were all significantly higher than that in baseline （P 〈 0.05）. There were no severe adverse effects in two groups. Conclusion Aripiprazole is effective to improve psychiatric symptoms of male patients with schizophrenia which has no effects on serum prolactin, blood sugar and body weight.
出处
《精神医学杂志》
2010年第4期277-279,共3页
Journal of Psychiatry
关键词
阿立哌唑
利培酮
精神分裂症
泌乳素
血糖
体重
Aripiprazole Risperidone Schizophrenia Serum prolactin Blood sugar Body weight
