摘要
系统性硬化病是一种以弥漫性血管病变及皮肤、内脏纤维化为主要特征的结缔组织疾病。本病少见,起病隐匿,累及心脏时常被其特有的心脏外表现所掩盖。但是,正确的运用一些辅助检查,我们可以发现几乎100%系统性硬化的病人合并有不同程度的心血管系统受累,且当患者出现心脏受累的临床表现后通常预后不良。因此如何早期发现系统性硬化病累及心脏尤为重要。
Systemic sclerosis （SSc） is a connective tissue disease characterized by diffused vascular lesions and fibrosis of the skin and major organs including heart, lung and kidney etc. Cardiac involvement, including primary myocardial involvement, is very common in SSc although it is often clinically asymptomatic. When sensitive measures of assessment are used, it has been estimated to occur in up to 100% of SSc patients. Cardiac involvement can be manifested by myocardial disease, conduction abnormalities and pericardial disease etc. Additionally, SSc renal crisis and pulmonary hypertension lead to significant cardiac dysfunction secondary to damage in the kidney and lung. Clinically evident cardiac involvement is recognized to be a poor prognostic factor; thus preclinical identification is highly encouraged.
出处
《中国分子心脏病学杂志》
CAS
2010年第4期254-256,共3页
Molecular Cardiology of China
关键词
系统性硬化病
心脏受累
治疗
Systemic sclerosis
Cardiac involvement
Treatment
