摘要
目的观察雷公藤多甙联合甲氨蝶呤治疗类风湿关节炎3个月的疗效及对外周血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的影响。方法将52例类风湿关节炎患者随机分为治疗组和对照组,各26例,治疗组接受雷公藤多甙联合甲氨蝶呤治疗,对照组接受甲氨蝶呤治疗,疗程均为3个月。观察2组治疗前后各项临床和实验室指标的变化,采用酶联免疫吸附法(ELISA)检测患者外周血清TNF-α和IL-6的表达变化。结果与对照组比较,治疗组各项临床和实验室指标均有明显好转,外周血清TNF-α、IL-6表达明显降低。结论雷公藤多甙联合甲氨蝶呤治疗类风湿关节炎疗效确切,能明显降低外周血清TNF-α、IL-6表达。
Objective To observe the efficacy of tripterygium wilfordii polyglycosidium （TWP） combined with methotrexate in treating rheumatoid arthritis for 3 months and its effect on the content of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） in peripheral serum. Methods Fifty-two patients with rheumatoid arthritis were randomly divided into treatment group （n =26） and control group （n =26）. The treatment group received TWP combined with methotrexate therapy, while the control group received methotrexate treatment only, the course of treatment was three months. The changes of various clinical and laboratory indicators were observed before and after treatment, and enzyme-linked immunosorbent assay was used to detect the content of TNF-α and IL-6 in peripheral serum. Results Compared with the control group, the clinical and laboratory parameters were significantly improved, and the expression of TNF-α and IL-6 in peripheral serum was significantly reduced in treatment group. Conclusions TWP combined with methotrexate has definite effect in treating rheumatoid arthritis, and can significantly reduce the expression of TNF-α and IL-6 in peripheral serum.
出处
《中国中医药信息杂志》
CAS
CSCD
2010年第9期7-9,共3页
Chinese Journal of Information on Traditional Chinese Medicine
