摘要
目的:检测复发性生殖器疱疹(RGH)患者血清细胞因子(IL-2、IL-12、TNF-γ)水平和外周血T淋巴细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)的分布,探讨生殖器疱疹(GH)患者反复发作的免疫学机制。方法:60例RGH患者和60例健康查体者为研究对象。采用流式细胞仪测定受试对象血清中IL-2、IL-12、TNF-γ水平和T淋巴细胞亚群水平。结果:RGH组血清细胞因子(IL-2、IL-12、TNF-γ)水平均显著低于对照组,相比较有显著性差异(P<0.05);RGH组患者外周血CD3+、CD4+、CD4+/CD8+T细胞明显低于对照组,相比较有显著性差异(P<0.05);而CD8+T细胞明显高于对照组,相比较有显著性差异(P<0.05)。结论:RGH患者血清中的细胞因子分泌出现异常,患者体内存在细胞免疫功能失调及免疫抑制现象。
Objective： Detecting the expression of cytokine and cellular immune analysis in peripheral blood of patients with recurrent genital herpes, discussing the immunological mechanism of repeated recurrence in genital herpes. Methods ： 60 cases of patients with recurrent genital herpes and 60 cases of health examination persons were as research object. The serum IL-2, IL- 12, TNF- γ levels and T lymphocyte subsets were detected by flow cytometry. Results： The serum cytokines （IL- 2, IL- 12, TNF - γ） of the RGH group were significantly lower than the control group, compared with control group the difference was significant （P 〈 0.05） ; The peripheral blood CD3 ＋ , CD4 ＋ and CD4 ＋ / CD8 ＋ T cells of the RGH group were significantly lower than the control group, compared with control group the difference was significant （ P 〈 0.05）, and the peripheral blood CD8 ＋ T cells of the RGH group were significantly higher than the control group, compared with control group the difference was significant （ P 〈 0.05）. Conclusion： The serum cytokine secretion of patients with RGH is abnormal. There are cellular immune dysfunction and immune suppression in the patients with RGH.
出处
《内蒙古中医药》
2010年第15期106-107,共2页
Inner Mongolia Journal of Traditional Chinese Medicine
