摘要
Toll样受体(Toll-like receptors,TLRs)是近几年来发现的在宿主体内发挥重要免疫应答作用的细胞表面受体分子,越来越多的证据表明TLRs可通过识别特定的模式分子,激活特定的信号转导通路,释放多种炎性介质和活性物质,在消化系统脏器损伤中起着至关重要的作用,如幽门螺杆菌(Helicobacter pylori,H.pylori)导致的胃黏膜损伤、酒精性胃炎、酒精性肝损伤、急性出血坏死性胰腺炎、肝缺血-再灌注损伤(ischemia/reperfusion injury,I/RI)、右旋硫酸钠(dextran sodium sulfate,DSS)诱导的结肠炎.本文对TLRs与消化系统脏器损伤的关系进行综述,初步探讨TLRs在消化系统疾病防治上的临床价值.
Toll-like receptors（TLRs） are cell-surface molecules that play an important role in the host immune response.More and more evidence indicates that TLRs can recognize special pattern molecules to activate certain signal transduction pathways and result in the release of numerous inflammatory mediators and active substances to induce digestive system injury,such as Helicobacter pylori infection-induced gastric mucosal injury,alcohol-induced gastritis,alcoholinduced liver injury,acute hemorrhagic necrotizing pancreatitis,hepatic ischemia-reperfusion injury（I/RI）,and dextran sodium sulfate（DSS）induced colitis.Here,we review the advances in understanding the relationship between TLRs and digestive system injury and explore the clinical value of TLRs in the diagnosis and treat-ment of digestive system diseases.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第22期2339-2345,共7页
World Chinese Journal of Digestology
基金
江苏省高校自然科学基金资助项目
No.09KJD310009
徐州医学院院长基金资助项目
No.09KJZ17~~
关键词
TOLL样受体
胃黏膜损伤
急性出血坏死性胰腺炎
肝损伤
结肠炎
Toll-like receptor
Gastric mucosal injury
Acute hemorrhagic necrotizing pancreatitis
Liver injury
Colitis
