摘要
骨髓间充质干细胞(BMSCs)在组织修复中具有重要的应用价值,它具有较低的免疫原性、自我更新能力和多向分化潜能,在一定的条件下体内外可以诱导分化为多种细胞类型。近年来研究表明力学因素通过多种信号途径可以影响BMSCs的多种生物学活性。综述了牵张应变、剪切应力、压应力和重力对BMSCs增殖、骨架和多向分化的影响。
Bone marrow mesenchymal stem cells(BMSCs) have shown great promise in tissue repair.While these cells induce little immune response,they show marked self-renewal properties and can differentiate into many cell types.Recent evidence shows that mechanical factors can regulate the biological behaviors of BMSCs through various signaling pathways.In this review,we will high-light the effects of strain,shear stress,compressive stress and gravity on the proliferation,cytoskeleton and differentiation of BMSCs.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2010年第4期920-923,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(10672015)
关键词
骨髓间充质干细胞
力学因素
分化
增殖
Bone marrow mesenchymal stem cells(BMSCs)
Mechanical factors
Differentiation
Proliferation