摘要
毛囊干细胞(FSC)具有慢增殖特性和多向分化潜能,维持着毛囊的变化和稳定以及皮肤创伤后的修复。FSC增殖分化机制的研究为毛发再生、皮肤疾病的治疗提供了新的途径。目前已知Wnt信号通路在调控FSC增殖分化中发挥着重要作用,而且不同的Wnt蛋白表现出不同的调控作用。现就Wnt信号通路对FSC的调控及不同Wnt蛋白的不同作用予以综述。
Hair follicle stem cells（FSCs）,which have characteristics of slow cycling and multipotential differentiations,play an important role in maintaining hair follicle cycling and repairing the epidermis during wound healing.The researches in this subject may be helpful to provide new ideals in treating the diseases of hair and skin.As we know,the Wnt signal transduction pathway has a significant meaning in controlling the proliferation and differentiation of FSCs,and different Wnt proteins have different functions in this process.In this paper,we review how the Wnt signal transduction pathway controls the FSCs and what the functions of different Wnt proteins are.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2010年第4期945-948,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(30871888)
关键词
毛囊干细胞
WNT信号通路
增殖
分化
Hair follicle stem cell（FSC）
The Wnt signal transduction pathway
Proliferation
Differentiation
